Prevalence of oral mucosal lesions and the association between diabetes mellitus and oral precancerous lesions among Malay patients attending Hospital Universiti Sains Malaysia
| dc.contributor.author | Al-Maweri, Dr. Sadeq Ali Ali Mohammed | |
| dc.date.accessioned | 2014-10-27T07:51:00Z | |
| dc.date.available | 2014-10-27T07:51:00Z | |
| dc.date.issued | 2009 | |
| dc.description | Master | en_US |
| dc.description.abstract | Introduction: Diabetes mellitus leads to a number of metabolic and immunological changes that affect the oral mucosa and it is associated with a variety of oral lesions and conditions. Specific lesions that have been identified in the past to be associated with DM include benign migratory glossitis, fissured tongue, median rhomboid glossitis, lichen planus, and parotid gland enlargement. Alterations in salivary flow rate and composition, which may contribute to the pathogenesis of some of these lesions have also been described. Objectives: This study was designed to determine the prevalence of oral mucosal lesions among Malay diabetic patients, the association between oral mucosal lesions and diabetes factors, and the association between diabetes and oral precancerous lesions. Methodology: This cross-sectional case-control study utilized 420 diabetic patients and 420 non-diabetic subjects in Hospital Universiti Sains Malaysia, Kota Bharu, Kelantan. Demographic information, duration and type of diabetes, glycosylated hemoglobin values (HbAc), history and current use of medication was obtained from medical records. Detail oral examination of the oral cavity was done based on international criteria and WHO codes. The number of remaining teeth and presence of dentures were also noted. Results: The frequency of oral mucosa lesions was significantly higher in diabetes patients that was 45% in comparison to 38.3% in controls (P=0.05). Twelve types of oral mucosal lesions were identified. Specific oral lesions which were found to be significantly of greater frequency in diabetes patients than controls include geographic tongue (P<0.01), denture stomatitis (P<0.05) and angular cheilitis (P=0.05). The prevalence of traumatic ulcers was higher in diabetics but this was not significant (P>0.5). About one-third of subjects in both groups used dentures and diabetic patients have a lower mean number of remaining teeth compared to non-diabetics (p<0.001). There was an association between the prevalence of oral mucosal lesions and metabolic control (P<0.05). However, no association between diabetes mellitus and oral precancerous lesions was found. Conclusions: Diabetic patients showed higher prevalence of oral mucosal lesions than controls. There is an association between oral mucosal lesions and metabolic control of diabetes. However, there was no an association between diabetes and oral precancerous lesions. | en_US |
| dc.identifier.uri | http://hdl.handle.net/123456789/172 | |
| dc.language.iso | en | en_US |
| dc.subject | Biological Science | en_US |
| dc.subject | Oral mucosal lesions | en_US |
| dc.subject | Diabetes mellitus | en_US |
| dc.subject | Oral precancerous lesions | en_US |
| dc.title | Prevalence of oral mucosal lesions and the association between diabetes mellitus and oral precancerous lesions among Malay patients attending Hospital Universiti Sains Malaysia | en_US |
| dc.type | Thesis | en_US |
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