Survival time and prognostic factors of AIDS patients in Kelantan : 2010-2014
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Date
2018-05
Authors
Ngah, Hamiza
Journal Title
Journal ISSN
Volume Title
Publisher
Pusat Pengajian Sains Perubatan, Universiti Sains Malaysia
Abstract
Background: The AIDS death is still a worldwide concern as well as in Kelantan.
However, the median survival time and predictor factors that contributing to risk of
death among AIDS patients in Kelantan were unknown.
Objectives: To determine the overall median survival time and survival rate of AIDS
patients and predictors factors of death in Kelantan population from 2010 to 2014.
Methodology: A retrospective cohort study was conducted in January 2018 using
secondary data obtained from National AIDS Registry for the period of 1st January
2010 to 31st December 2014 and followed-up until 31st Mac 2015. A complete 1073
data was selected for descriptive analysis and survival analysis. Kaplan- Meier survival
analysis and Cox’s proportional hazard regression model with estimates of hazard ratio
and 95% confidence interval were used.
Result: The mean (SD) age was 37.08 (7.37). The patients were predominantly males
(87.0%), Malays (87.5%), single (62.3%), unemployed (38.0%), with background of
secondary education (78.1%) and cases without HIV-TB co-infection (62.8%).
Approximately 53% of the patients death during follow-up. The overall median
survival time was 11 months. The probability of survival in 1-year, 2-year and 5-year
were 49.1%, 47.8%, and 46.7% respectively. Multivariate Cox regression showed that
significant prognostic factors were age 30-49 years (Adj. HR 1.57; 95% CI: 1.14, 2.16;
p=0.006), male (Adj. HR 1.39; 95% CI: 1.07, 1.79; p=0.012), unemployed (Adj. HR
Description
Keywords
Acquired immunodeficiency syndrome