Association Analysis Of Single Nucleotide Polymorphism Of Opioid Dependence Genes Among Malay Males In Malaysia
| dc.contributor.author | Devaki Nagaya | |
| dc.date.accessioned | 2021-03-01T01:18:31Z | |
| dc.date.available | 2021-03-01T01:18:31Z | |
| dc.date.issued | 2018-09 | |
| dc.description.abstract | Drug addiction is a chronic and relapsing disorder is associated with genetics. There are many studies have been reported the roles of single nucleotide polymorphisms (SNPs) with drug dependence and among those, twelve (12) candidate genes that were associated with drug dependence will be investigated in this study. The candidate genes are OPRD1 (Delta Opioid Receptor), OPRK1 (Kappa Opioid Receptor), COMT (Catechol – O-Methyltransferase gene), PDYN (Prodynorphin), DRD4 (Dopamine receptor D4), ABCB1(P glycoprotein), DUSP (Dual Specificity Phosphatase 27) and rs10494334. The goal of this study was to determine the frequencies of these SNPs rs1042114, rs702764, rs199774, rs1022563, rs910080, rs737866, rs10494334, rs1800955, rs1128503, rs1045642, and rs2032582 and to study their association with opioid dependence in Malay males in Malaysian population. This genetic database will be established for pharmacogenetics-based treatment. Research participants were 459 Malay males with opioid dependence and 543 healthy Malay males as controls. SNPs were genotyped using TaqMan SNP genotyping assay. Statistical analysis was performed using Golden Helix SVS software suite to identify the distribution of allele and genotype frequencies and SNP–SNP interactions. Database was developed using MySQL - the de-facto standard database that runs on a protected server. SNPs rs1042114 of OPRD1, rs910080 of PDYN, r1800955 of DRD4, rs1128503, rs1045642,and rs2032582 of ABCB1 were strongly associated with opioid addiction at allelic level with p<0.05. A statistically significant interaction was also identified between most of the risk alleles of all the SNPs associated with drug addictions with other polymorphism studied in this research. The database established on drug addiction SNPs from this research will be useful for clinicians in the understanding of the effects of SNPs and the SNP–SNP interaction on opioid dependence to treat the drug dependence patients effectively without adverse drug responses. | en_US |
| dc.identifier.uri | http://hdl.handle.net/123456789/11588 | |
| dc.language.iso | en | en_US |
| dc.publisher | Universiti Sains Malaysia | en_US |
| dc.subject | Medicine | en_US |
| dc.subject | Drug addiction | en_US |
| dc.title | Association Analysis Of Single Nucleotide Polymorphism Of Opioid Dependence Genes Among Malay Males In Malaysia | en_US |
| dc.type | Thesis | en_US |
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