Design And Evaluation Of Multiparticulate Systems Prepared Using Sieving-Spheronisation And Extrusion-Spheronisation

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dc.contributor.authorKarim, Sabiha
dc.date.accessioned2018-10-11T01:41:34Z
dc.date.available2018-10-11T01:41:34Z
dc.date.issued2011-03
dc.description.abstractPelletised dosage forms can be prepared by different methods which, in general, are time consuming and labor intensive. The current study was carried out to assess the feasibility of preparing spherical pellets by sieving the wet powder mass followed by spheronisation. This method was compared with extrusion-spheronisation process in terms of physical characteristics and in-vitro dissolution profile of the developed formulations. The fast release paracetamol pellets were comprised of, microcrystalline cellulose, lactose, crospovidone and polyvinyl pyrrolidone-K90. The percentage yield of paracetamol pellets produced by sieving-spheronisation was higher (p<0.05) in comparison with that produced by extrusion-spheronisation. The extrusionspheronisation showed better flowability (p<0.05) than sieving-spheronisation. However, no significant difference was found in other physical properties of two methods. The dissolution profile was slightly higher in sieving-spheronisation technique, the similarity factors showed that dissolution profiles can be considered comparable in the formulations prepared by two methods and followed first order kinetics. The rate of drug release was essentially independent of pH and agitation rate. Omeprazole spherical pellets with required release rate were developed using sieving-spheronisation process. Pellets with desired characteristics were obtained with minimum amount of microcrystalline cellulose (16%), lactose, polyvinylpyrrolidone K30, polyethylene glycol 6000 and sodium lauryl sulfate. Pellets prepared by sieving-spheronisation showed significantly higher (p<0.05) percentage yield as compared to that of extrusionspheronisation. Omeprazole delay release system was developed by Kollicoat 30DP, using bottom spray fluidised bed system. Coating level of 17.5 % prevented the drug release less than 10% at pH 1 for initial 2 hours and at pH 6.8 release was 80 to 84% within 45 minutes, following the first order release kinetics. In accelerated stability studies, both drugs followed the zero order degradation.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/6739
dc.language.isoenen_US
dc.publisherUniversiti Sains Malaysiaen_US
dc.subjectFeasibility of preparing spherical pelletsen_US
dc.subjectwet powder mass followed by spheronisationen_US
dc.titleDesign And Evaluation Of Multiparticulate Systems Prepared Using Sieving-Spheronisation And Extrusion-Spheronisationen_US
dc.typeThesisen_US
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