Effects Of Cessation Of Exercise And Honey Supplementation On Bone Properties And Antioxidant Status In Young Female Rats And Humans

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dc.contributor.authorTavafzadeh Haghi, Somayeh Sadat
dc.date.accessioned2017-09-12T06:55:52Z
dc.date.available2017-09-12T06:55:52Z
dc.date.issued2017-02
dc.description.abstractResearch findings on the effects of detraining and termination honey supplementation on bone properties and antioxidant status is lacking in the literature. This study aims to investigate effects of cessation of exercise and honey supplementation on bone properties and antioxidant status in young female rats and humans. At phase one, eighty-four 12-week-old Sprague-Dawley female rats were divided into 7 groups: 16S, 16J, 16H, 16JH, 8J8S, 8H8S, and 8JH8S (8=8 weeks, 16=16 weeks, S=sedentary, H=honey supplementation and J=jumping exercise). Jumping exercise consisted of 40 jumps/day for 5 days/week. Honey was given to the rats at a daily dosage of 1 g/kg body weight/rat/day via force feeding. Jumping exercise and honey supplementation were terminated for 8 weeks in 8J8S, 8H8S, and 8JH8S groups. Tibial and femoral mass, bone mineral density (BMD), mid-shaft cortical area and moment of inertia (MOI), mechanical properties, dimensions, bone metabolism markers and related hormones, antioxidant status and oxidative stress markers were measured after 16 weeks of study period. At phase two, forty-eight young female college students aged between 19-25 years old were recruited and assigned into 4 groups: 16S, 8Ex8S, 8H8S and 8ExH8S (8=8 weeks, 16=16 weeks, S=sedentary, H=honey supplementation and Ex=aerobic dance exercise). Aerobic dance exercise sessions consisted of 1 h of aerobic dance exercise per session, 3 sessions per week for 8 weeks. Honey was consumed at a daily dosage of 20g/day for 8 weeks. Aerobic dance exercise and honey supplementation were terminated for another 8 weeks in 8Ex8S, 8H8S, and 8ExH8S groups. Parameters measured at pre-, mid- and post tests included body mass, body mass index (BMI), percentage of body fat, bone speed of sound (SOS) (indicator of bone mineral density), muscular strength and power, bone metabolism markers, antioxidant status and oxidative stress markers. In phase one, after 8 weeks of cessation of jumping exercise and honey supplementation, tibial and femoral wet weight, fat free dry weight, proximal total BMD, energy, minimum diameter, serum total calcium, osteocalcin, calcitonin and TAS were significantly higher and serum 1CTP was significantly lower in 8JH8S as compared to 16S. Meanwhile mid-shaft cortical MOI and cortical area, as well as maximal load were significantly higher in tibia of 8JH8S, and mid-shaft cortical BMD and maximum diameter were significantly higher in femur of 8JH8S as compared to 16S. It was also found that continuous sixteen weeks of combined jumping and honey (16JH) resulted in significant greater tibial and femoral wet weight, fat free dry weight, proximal total BMD, trabecular BMD, mid-shaft cortical BMD, maximal load, maximum force, energy, minimum diameter, serum total calcium, ALP, osteocalcin, calcitonin, TAS, blood SOD, GSH and GSH/GSSG ratio, as well as lower serum 1CTP and PTH when compared to 16S. Meanwhile mid-shaft cortical MOI and cortical area were significantly higher only in tibial of 16JH and maximum diameter was significantly higher in femur of 16JH as compared to 16S.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/4617
dc.language.isoenen_US
dc.publisherUniversiti Sains Malaysiaen_US
dc.subjectTermination honey supplementationen_US
dc.subjecton bone properties.en_US
dc.titleEffects Of Cessation Of Exercise And Honey Supplementation On Bone Properties And Antioxidant Status In Young Female Rats And Humansen_US
dc.typeThesisen_US
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