BIOINFORMATICS: INFERENCE OF POPULATION GENETIC STRUCTURE OF PENINSULAR MALAYSIA MALAY SUB-ETHNIC GROUPS USING SINGLE NUCLEOTIDE POLYMORPHISMS (SNPs) MICROARRAY MULTILOCUS GENOTYPE DATA
| dc.contributor.author | W. NUR HATIN, W. ISA | |
| dc.date.accessioned | 2017-11-01T02:44:02Z | |
| dc.date.available | 2017-11-01T02:44:02Z | |
| dc.date.issued | 2012-05 | |
| dc.description.abstract | In Peninsular Malaysia, the Malays consist of various sub-ethnic groups which are believed to have different ancestral origins based on their migrations centuries ago. Knowledge of Malay population genetic structure is not just important for a proper design of biomedical studies, but also helpful in understanding their demographic histories of migration and admixture. This study was conducted with the aim of identifying and analyzing the genetic structures and ancestral membership coefficients of five Malay sub-ethnic groups namely Melayu Bugis, Melayu Jawa, Melayu Minang, Melayu Kedah, and Melayu Kelantan. The multilocus genotype data of single nucleotide polymorphisms (SNPs) for all of the Malay sub-ethnic groups were generated using Affymetrix 50K Array chip. For powerful inference, 12 other study populations from Thailand, Indonesia, China, India, Africa and Orang Asli sub-groups in Malay Peninsula, obtained from the Pan Asian SNP Initiative (PASNPI) and International HapMap project database, were included in the analysis. The genotyped data of 54,794 autosomal SNPs for each of 472 individuals from the 17 populations were analyzed by two statistical analyses approaches for genetic clustering, which are distance-based and model-based clustering methods. The distance-based method has successfully detected at least three genetic clusters, implying probable admixtures within the Malays. Melayu Bugis and Melayu Minang have a very close genetic relationship with Indonesian populations, whilst Melayu Jawa have interestingly close genetic relationship with Proto-Malays Temuan and Chinese, indicating a common ancestral origin. Melayu Kedah and Melayu Kelantan are genetically different from the other Malay sub-ethnic groups, but close to Thai Pattani. The model-based method has uncovered the level of admixture and ancestral membership coefficient for each of the Malays. Apparently, Malays shared a common ancestor with the Indonesians and Thais. The ancestry lines of Malays, Indonesians and Thais were traced back to have shared a common ancestor with the Proto-Malays and Chinese. Nevertheless, Melayu Kedah and Melayu Kelantan have substantial Indian ancestral component in their genome, as well as the Melayu Minang, relative to the other Malays. The Melayu Jawa had the highest proportions of Chinese ancestral component in their genome, whilst the Melayu Bugis had almost no admixture in their genome. These results contribute significantly on the genetic differentiation between the Malays sub-ethnic groups and provided valuable insight into the origins of the Malays in the Malay Peninsula. | en_US |
| dc.identifier.uri | http://hdl.handle.net/123456789/5206 | |
| dc.language.iso | en | en_US |
| dc.publisher | Pusat Pengajian Sains Perubatan Universiti Sains Malaysia | en_US |
| dc.subject | General Medicine | en_US |
| dc.title | BIOINFORMATICS: INFERENCE OF POPULATION GENETIC STRUCTURE OF PENINSULAR MALAYSIA MALAY SUB-ETHNIC GROUPS USING SINGLE NUCLEOTIDE POLYMORPHISMS (SNPs) MICROARRAY MULTILOCUS GENOTYPE DATA | en_US |
| dc.type | Thesis | en_US |
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