The Effect Of Aerosolised-Honey On Inflammation, Regeneration And Repair Of Airway Epithelia In Rabbit Model Of Ovalbumin-Induced Chronic Lung Injury
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Date
2017-08
Authors
Kamaruzaman, Nurfatin Asyikhin
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Publisher
Universiti Sains Malaysia
Abstract
For the past few decades, chronic lung injury has attributed to thousands of death worldwide. The disease occurred due to alteration in the structure as well as cellular components of the airways which later lead to airway remodelling and inflammation. This disease is not curable; however, treatments are available to reduce the disease symptoms and preventing the disease progression. At the clinical setting, conventional drug therapy is available to lessen disease exacerbations; however, there is still a need to find the alternative treatments that incorporated with natural resources to minimize the side effect of drug therapy. The general objective of this study was to study the effect of aerosolised-honey on airway epithelium repair and regeneration following ovalbumin-induced chronic lung injury in rabbit model. Injury was first introduced in the rabbit model by ovalbumin sensitization and treatment of aerosolised-Tualang honey was given to the animals using a nebuliser. Two models had been developed with the aim to investigate the potentiality of Tualang honey to serve as rescue agent by providing quick relief upon disease symptoms or as preventive agent (to prevent the progression of the disease). Research was carried out using two concentrations of Tualang (Koompassia Excelsa) honey; 25% and 50%. Current study was focussing on the histological effect of aerosolised-honey treatment towards three parameters of chronic lung injury; (1) restoration of airway structures, (2) improving and/or eliminating the goblet cell hyperplasia, and (3) reducing the inflammatory cells infiltration. Results between the treatment groups, naive and control groups were statistically compared. Aerosolised-Tualang honey (regardless of any concentration and modes of action) was shown to be able to alleviate the disease symptoms by restoring the airway structures, eliminating the goblet cell hyperplasia and reducing the eosinophils infiltration. These findings provide the evidence that aerosolised-honey can act as both rescue and preventive agents, thus it could be useful to be applied as alternative treatment in managing the chronic lung injury patients in future.
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Keywords
Chronic lung injury has attributed to , thousands of death worldwide.