Evaluation Of Image Quality And Radiation Dose On Gold Nanoparticles And Other Clinical Contrast Agents In Abdominal Computed Tomography Phantom
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Date
2018-07
Authors
Mohd Zukhi, Nur Jihan
Journal Title
Journal ISSN
Volume Title
Publisher
Universiti Sains Malaysia
Abstract
Some medical conditions need multiple contrast agents’ administration when multiple target organs are needed for diagnostic imaging. Currently, there is no abdominal phantom that can analyse the image quality of multiple contrast agents and radiation dose simultaneously. Thus, the gold nanoparticles and other clinical contrast agents were used in this study using a fabricated abdominal phantom. The aim of this study was to evaluate the image quality and radiation dose using several contrast agents (gold nanoparticles, barium, iodine, gadolinium, and milk) in abdominal computed tomography (CT) phantom. Abdomen phantom of 32 cm diameter was fabricated from polymethyl methacrylate with five sets of optically stimulated luminescence dosimeter slots and the cylindrical contrast agent tubes with 6 cm diameter that attached together. The gold nanoparticles contrast agent was synthesised in a nanosphere shape with the average size of 55 nm. The concentration for gold nanoparticles, barium, iodine, and gadolinium are 1.1 mgml-1, 12.0 mgml-1, 7.6 mgml-1, and 1.6 mgml-1, respectively. 35.0 mgml-1 (4%) fat in milk was used in this study. Three optically stimulated luminescence dosimeters were placed in each contrast agent tube to measure the radiation dose. The phantom was scanned with various tube voltage at 80 kV, 120 kV, and 140 kV in single-energy mode and tube voltage was set at 80 kV and 140 kV in dual-energy mode. The pitches were set at 0.6 and 1.0, and the
slice thickness were set at 3.0 mm and 5.0 mm. The contrast-to-noise ratio of all contrast agents increases with the increment of slice thickness as more photons are captured.
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Keywords
Evaluation of image quality and radiation dose on gold nanoparticles , in abdominal computed tomography phantom