Fabrication and characterization of bioactive glass microspheres
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Date
2019-06
Authors
Nursyazwani Binti Ismail
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Abstract
Bioactive glass microspheres (BGM) has drawn many research interest in
biomedical applications due to its biocompatibility and biodegradable properties. In this
research work, BGM are fabricated through modified melt-quench-emulsion with the
concept of Pickering emulsion method. The composition of 45S5 silicate-based
bioactive glass (BG) is used for the fabrication of BGM. The non-treated silica particles
are too hydrophilic, which may reduce the usability for Pickering emulsion. In order to
obtain a stable emulsions, in this study, surface modification on the BG were done using
3-aminopropyltriethoxysilane (APTES) and oleic acid (OA) to increase the
hydrophobicity of the silica particles. The outcome of surface treatment on the BG
powders were investigated. Pickering emulsion with volume ratio of oil to water at 6:4
was formed with DCM and treated BG powder as oil phase, and polyvinyl alcohol
(PVA) and deionized (DI) water as the aqueous phase. Characterization involved are X
ray Diffraction (XRD), Fourier Transform Infrared Spectrometry (FTIR) and Scanning
Electron Microscope (SEM), immersion in Hank’s Balance Salt Solution (HBSS) and
pH measurement. The results found that the BG powders show the formation of
combeite phase after heat treated at 560°C and surface treatment on the BG do not affect
the crystallinity of the samples. Through characterization testing, the results found that
the silane-modified particles shows great stability in emulsion than the modified
particles using oleic acid, and microspheres can be formed for both samples. The
precipitate form after being immersed in HBSS were observed for all samples.