Fabrication and characterization of bioactive glass microspheres
| dc.contributor.author | Nursyazwani Binti Ismail | |
| dc.date.accessioned | 2021-02-09T04:09:03Z | |
| dc.date.available | 2021-02-09T04:09:03Z | |
| dc.date.issued | 2019-06 | |
| dc.description.abstract | Bioactive glass microspheres (BGM) has drawn many research interest in biomedical applications due to its biocompatibility and biodegradable properties. In this research work, BGM are fabricated through modified melt-quench-emulsion with the concept of Pickering emulsion method. The composition of 45S5 silicate-based bioactive glass (BG) is used for the fabrication of BGM. The non-treated silica particles are too hydrophilic, which may reduce the usability for Pickering emulsion. In order to obtain a stable emulsions, in this study, surface modification on the BG were done using 3-aminopropyltriethoxysilane (APTES) and oleic acid (OA) to increase the hydrophobicity of the silica particles. The outcome of surface treatment on the BG powders were investigated. Pickering emulsion with volume ratio of oil to water at 6:4 was formed with DCM and treated BG powder as oil phase, and polyvinyl alcohol (PVA) and deionized (DI) water as the aqueous phase. Characterization involved are X ray Diffraction (XRD), Fourier Transform Infrared Spectrometry (FTIR) and Scanning Electron Microscope (SEM), immersion in Hank’s Balance Salt Solution (HBSS) and pH measurement. The results found that the BG powders show the formation of combeite phase after heat treated at 560°C and surface treatment on the BG do not affect the crystallinity of the samples. Through characterization testing, the results found that the silane-modified particles shows great stability in emulsion than the modified particles using oleic acid, and microspheres can be formed for both samples. The precipitate form after being immersed in HBSS were observed for all samples. | en_US |
| dc.identifier.uri | http://hdl.handle.net/123456789/11209 | |
| dc.language.iso | en | en_US |
| dc.title | Fabrication and characterization of bioactive glass microspheres | en_US |
| dc.type | Other | en_US |
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