Herb-Drug Interactions In Cancer Treatment: A Systematic Review

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dc.contributor.authorChow, Lee Fun
dc.date.accessioned2021-01-18T08:43:16Z
dc.date.available2021-01-18T08:43:16Z
dc.date.issued2019
dc.description.abstractBesides standard anti-cancer drugs, the use of herbs has been steadily increased as complementary and alternative medicine among cancer patients. This may cause potential pharmacokinetic herb-drug interactions at different levels or processes. For this reason, several studies had been conducted to explore any potential changes in pharmacokinetic parameters caused by herb-drug interaction. This review aimed to systematically compile and analyze all the evidence-based findings related to pharmacokinetic herb-drug interaction in cancer treatment which were published from year 2008 to 2019. These articles were searched via electronic databases and selection process was carried out based on the predefined inclusion criterias. The data of the studies were extracted according to bioactive constituents, anti-cancer drug, type of cancer, study design, mode of action and changes of pharmacokinetic parameters. A total of 21 articles reported finding related to pharmacokinetic herb-drug interactions in cancer treatment were included in this review. A total of 10 different herbs and 14 different anti-cancer drugs had been studied for pharmacokinetic interactions. Majority of the articles explained about absorption and metabolism as the main mechanisms which had been induced or inhibited by herb-drug interaction. CYP3A4 was found to be the most targeted anti-cancer drug. The most common method of investigation used in the pharmacokinetic herb-drug interactions was through in vivo study. This systematic review also found that breast cancer, docetaxel and ginseng were the most common type of cancer, anti-cancer drug and herb which had been used in investigating the pharmacokinetic herb-drug interaction respectively. Based on the aforementioned findings, there are still gaps in knowledge regarding pharmacokinetic herb-drug interactions in cancer treatment. Therefore, further research need to be explored and determined in future especially related to its safety and efficacy profiles.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/10891
dc.language.isoenen_US
dc.publisherUniversiti Sains Malaysiaen_US
dc.subjectHerb-drug interactionsen_US
dc.subjectcancer treatmenten_US
dc.titleHerb-Drug Interactions In Cancer Treatment: A Systematic Reviewen_US
dc.typeThesisen_US
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