The Role Of FDG PET-CT In Detection Of Recurrent Colorectal Cancer In National Cancer Institute, Putrajaya, Malaysia

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dc.contributor.authorWong, Teck Huat
dc.date.accessioned2017-10-09T06:25:16Z
dc.date.available2017-10-09T06:25:16Z
dc.date.issued2016
dc.description.abstractThis study aimed to determine the role of 18F-Fluorodeoxyglucose (FDG) PET-CT in detection of recurrent colorectal cancer in our institution as well as to correlate factors which may influence diagnostic performance of PET-CT. An Ethics Board (from Universiti Sains Malaysia and Medical Research & Ethics Committee, MREC) approved retrospective study was performed in National Cancer Institute, Putrajaya from January to December 2014, recruiting all consecutive patients with treated colorectal cancer and was suspected to have recurrence based on CEA levels or CT imaging. PET-CT images were reviewed by a dedicated senior nuclear medicine consultant. Histopathology or clinical and imaging follow up for at least six months were used as reference standard to confirm the final diagnosis. 16 of 85 patients recruited were excluded from analysis due to unavailability of follow up data. In the other 69 patients (M:F = 41:28), recurrence was diagnosed in 39.1%. Sensitivity, specificity, positive predictive value, negative predictive value and accuracy of PET-CT in detecting recurrent colorectal cancer in this study were 92.6%, 88.1%, 83.3%, 94.9% and 89.9% respectively. PET-CT had high diagnostic performance to evaluate patients with elevated CEA levels and with suspicious CT findings. It was more accurate than CT in detecting the true locations of recurrence and could detect more sites of recurrence. Patients with rising CEA level but still within normal limit and normal CT imaging had low risk of recurrence (0% in this study) and were likely not indicated for PET-CT imaging. In conclusion, PET-CT is sensitive and specific in detecting recurrent colorectal cancer.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/4845
dc.language.isoenen_US
dc.publisherUniversiti Sains Malaysiaen_US
dc.subjectThe Role Of FDG PET-CT In Detection Ofen_US
dc.subjectRecurrent Colorectal Canceren_US
dc.titleThe Role Of FDG PET-CT In Detection Of Recurrent Colorectal Cancer In National Cancer Institute, Putrajaya, Malaysiaen_US
dc.typeThesisen_US
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