Rational Drug Design Of New Folic Acid Analogues With High Binding Affinity And Anticancer Activity
Loading...
Date
2020-10
Authors
Althiabat, Mohammad Gasem Mohammad
Journal Title
Journal ISSN
Volume Title
Publisher
Universiti Sains Malaysia
Abstract
The goal of this thesis is to design new FA analogues with higher selectivity to bind with FRα. Fifty FA-analogues with variant heterocyclic rings were designed and studied for their interaction with FRα. Docking results showed 20 out of the 50 FA-analogues showed higher binding affinity than methotrexate (MTX) and the parent folic acid (FA) towards FRα.
Description
Keywords
Rational Drug Design , New Folic Acid Analogues , High Binding Affinity , Anticancer Activity