Rational Drug Design Of New Folic Acid Analogues With High Binding Affinity And Anticancer Activity

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dc.contributor.authorAlthiabat, Mohammad Gasem Mohammad
dc.date.accessioned2022-07-21T01:37:13Z
dc.date.available2022-07-21T01:37:13Z
dc.date.issued2020-10
dc.description.abstractThe goal of this thesis is to design new FA analogues with higher selectivity to bind with FRα. Fifty FA-analogues with variant heterocyclic rings were designed and studied for their interaction with FRα. Docking results showed 20 out of the 50 FA-analogues showed higher binding affinity than methotrexate (MTX) and the parent folic acid (FA) towards FRα.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/15614
dc.language.isoenen_US
dc.publisherUniversiti Sains Malaysiaen_US
dc.subjectRational Drug Designen_US
dc.subjectNew Folic Acid Analoguesen_US
dc.subjectHigh Binding Affinityen_US
dc.subjectAnticancer Activityen_US
dc.titleRational Drug Design Of New Folic Acid Analogues With High Binding Affinity And Anticancer Activityen_US
dc.typeThesisen_US
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