Rbc parameters, vitamin b12, folate, homocysteine levels and mthfr gene polymorphism in postmenopausal Malay women and their relation to hormone replacement therapy.

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dc.contributor.authorAl Jabr, Mohamed Talal Abd Alfattah
dc.date.accessioned2018-12-13T06:04:37Z
dc.date.available2018-12-13T06:04:37Z
dc.date.issued2011
dc.description.abstractHiperhomosisteinemia terjadi disebabkan oleh penurunan aras kofaktor-kofaktor (vitamin B12, B6 dan folat) dan / atau akibat kekurangan keberkesanan enzim methylene tetrahydrofolate reductase (MTHFR). Keadaan ini telah dikaitkan dengan risiko kejadian ‘atherosclerosis’ yang merupakan salah satu factor penyumbang kepada penyakit jantung koronari di kalangan wanita menopaus. Adalah tidak di ketahui samada perubahan pada parameter-parameter sel darah merah boleh terjadi tanpa melibatkan ketidak normalan pada aras vitamin B12 dan folat di kalangan wanita menopaus yang berkaitan dengan kehadiran hiperhomosisteinemia. Hyperhomocysteinemia occurs as a result of decreased levels of cofactors (vitamin B6, vitamin B12 and folate) and/or reduced efficiency of Methylenetetrahydrofolate reductase (MTHFR) enzyme. Hyperhomocysteinemia is an independent risk factor for atherosclerosis and may be one of the factors predisposing for coronary heart disease (CHD) in postmenopausal women. It is not well known whether changes in red blood cells parameters can occur independently of B12 and folate abnormalities in postmenopausal women in association with hyperhomocysteinemia.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/7290
dc.language.isoenen_US
dc.publisherUniversiti Sains Malaysiaen_US
dc.subjectHormoneen_US
dc.subjectTherapyen_US
dc.titleRbc parameters, vitamin b12, folate, homocysteine levels and mthfr gene polymorphism in postmenopausal Malay women and their relation to hormone replacement therapy.en_US
dc.typeThesisen_US
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