Randomised double-blind comparison of morphine vs a morphine-alfentanil combination for patient-controlled analgesia
| dc.contributor.author | Alias, Anita | |
| dc.date.accessioned | 2017-08-23T06:18:36Z | |
| dc.date.available | 2017-08-23T06:18:36Z | |
| dc.date.issued | 2002-04 | |
| dc.description.abstract | Patient-controlled analgesia (PCA) has been used for the past 30 years as an alternative method to administer postoperative analgesia. Patient-Controlled Analgesia allows patients to self-administer small boluses of opioids, providing better dose titration and regulation. The quantity of analgesic available to the patient is limited by the prescribed patient-controlled analgesia variables; demand dose size, lockout period and hourly or 4-hourly limits. In a randomized, double-blind study, I compared a combination of morphine and alfentanil with morphine alone for patient-controlled analgesia after Caesarean section under spinal anesthesia. After surgery, patients were randomly allocated to receive patient-controlled analgesia with a bolus dose of either morphine 0.75 mg plus alfentanil 0.125 mg (Group MA, n= 40) or morphine 1.5 mg alone (Group M, n=40) with a lockout interval of 8 minute and no hourly dose limit or basal infusion. Clinical assessments were made in the first 24 hours, after which patients completed a written questionnaire. There was a significance difference between groups in patient-controlled analgesia usage with the mean of patient-controlled analgesia boluses received by group MA bigger (41.0) as compared to group M (27.4) but the visual analogue scale scores of pain measured at 2, 4, 6 and 24h were not significant. There was a low incidence of side-effects in both groups. In the questionnaires, there were no differences in grading for speed of onset, effectiveness of analgesia, duration of analgesia and overall patient satisfaction. Addition of alfentanil to morphine does not have any advantages for patient-controlled analgesia. | en_US |
| dc.identifier.uri | http://hdl.handle.net/123456789/4412 | |
| dc.language.iso | en | en_US |
| dc.publisher | Universiti Sains Malaysia | en_US |
| dc.subject | Patient-controlled analgesia (PCA) | en_US |
| dc.title | Randomised double-blind comparison of morphine vs a morphine-alfentanil combination for patient-controlled analgesia | en_US |
| dc.type | Thesis | en_US |
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