Genetic Polymorphisms Of Cyp2c19 And The Effect Of Cyp2c19*2 On Clopidogrel P2y12 Inhibition In Healthy Malaysian Volunteers

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dc.contributor.authorSani, Yanti Nasyuhana
dc.date.accessioned2019-12-05T01:45:22Z
dc.date.available2019-12-05T01:45:22Z
dc.date.issued2014-02
dc.description.abstractThe CYP2C19*2 may be associated with reduced antiplatelet effects for clopidogrel. Therefore, the frequencies of CYP2C19*2 and CYP2C19*3 in the study population were investigated using PCR-direct sequence-based method. Subsequently, the influence of CYP2C19*2 on antiplatelet effects of clopidogrel in 45 healthy Malaysian subjects were investigated. The information on the predictive ability of CYP2C19 genotype with phenotype to adequately predict clopidogrel responsiveness of 90 voluntary subjects was determined. Ninety subjects were genotyped for CYP2C19*2 and CYP2C19*3. However, of the 90 subjects who were genotyped for CYP2C19*2 and CYP2C19*3, 45 of them were included in the clopidogrel response study and triaged into 3 genotypes, namely CYP2C19*1/*1 (n = 17), CYP2C19*1/*2 (n = 21) and CYP2C19*2/*2 (n = 7). All subjects received 300 mg of clopidogrel and platelet reactivity was assessed after 4 hr loading utilizing the VerifyNow-P2Y12 assay. Platelet activity was reported using P2Y12 Reaction Units (PRU), percent of inhibition and mean PRU changes. Nonresponder status was prespecified at PRU ≥ 230, irrespective of genotype group.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/9270
dc.language.isoenen_US
dc.publisherUniversiti Sains Malaysiaen_US
dc.subjectCyp2c19en_US
dc.subjectClopidogrel P2y12en_US
dc.titleGenetic Polymorphisms Of Cyp2c19 And The Effect Of Cyp2c19*2 On Clopidogrel P2y12 Inhibition In Healthy Malaysian Volunteersen_US
dc.typeThesisen_US
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