Antidiabetic Activity Of Nypa Fruticans WURMB. Vinegar
| dc.contributor.author | Md Yusoff, Nor Adlin | |
| dc.date.accessioned | 2019-08-05T02:11:12Z | |
| dc.date.available | 2019-08-05T02:11:12Z | |
| dc.date.issued | 2017-02 | |
| dc.description.abstract | Nypa fruticans Wurmb. vinegar, locally known as nipa palm vinegar (NPV) in Malaysia, is believed to have remarkable antidiabetic properties. This study sought to elucidate the vinegar’s antidiabetic activity and possible mechanisms of action. Liquid– liquid extraction was used to separate the compounds in NPV based on polarity into an ethyl acetate extract (EE) and an aqueous extract (AE). AE was further fractionated using acid hydrolysis into two sub-fractions: SFI and SFII. NPV, EE, AE, SFI and SFII were administered using oral gavage in non diabetic and/or diabetic rats induced by streptozotocin (STZ). Blood glucose levels (BGLs), insulin levels, and liver and pancreatic histological changes were recorded. In vitro effects of AE on α–glucosidase and α–amylase activities, as well as on glucose absorption/ uptake in isolated rat jejunal sacs/ skeletal muscles; were observed. No acute hypoglycemic effect was shown in non diabetic rats upon administering up to 1 g/kg of NPV, EE or AE. Nevertheless, NPV and AE significantly ameliorated high BGLs at 90 minutes in glucose-loaded rats. Yet, administration of NPV, EE and AE to STZ-induced diabetic rats showed no antihyperglycemic effects for up to 7 h. Sub-chronic 12-day oral treatment in diabetic rats revealed that AE had a superior antihyperglycemic activity overall. Immunohistochemical assessment of the animals’ pancreatic tissues showed that, albeit having no regenerative effect, AE stimulated the secretion of insulin from viable β– cells. It also precipitated structural recovery in the liver. It lowered BGLs, improved serum insulin levels and normalized the lipid profile of the animals, with no signs of gastric ulcer or abnormal body weight gain/loss. Consequently, AE was chosen for xvii elaborate antidiabetic mechanism studies. In vitro tests showed that AE inhibited the absorption of glucose from jejunum. | en_US |
| dc.identifier.uri | http://hdl.handle.net/123456789/8567 | |
| dc.language.iso | en | en_US |
| dc.publisher | Universiti Sains Malaysia | en_US |
| dc.subject | Nypa fruticans Wurmb. vinegar | en_US |
| dc.subject | remarkable antidiabetic properties | en_US |
| dc.title | Antidiabetic Activity Of Nypa Fruticans WURMB. Vinegar | en_US |
| dc.type | Thesis | en_US |
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