Interaction of sympathetic nervous system and renin angiotensin system in systemic circulation of cardiac hypertrophic rat model with gα protein expression interface.
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Date
2010-09
Authors
Hussain, Nurjannah Mohamad
Journal Title
Journal ISSN
Volume Title
Publisher
Universiti Sains Malaysia
Abstract
Penyelidikan ini mengkaji kaitan di antara sistem saraf simpatetik (SNS) dan sistem renin angiotensin (RAS) di dalam hipertrofi jantung. Kajian hemodinamik dilakukan untuk menilai respon vasokonstriksi adrenoseptor (iaitu adrenoseptor α1 dan β1) dan reseptor angiotensin II jenis 1 (AT1) untuk memahami peranan fungsi SNS dan RAS dengan menggunakan model tikus hipertrofi jantung.
The present study investigates the interrelation between sympathetic nervous system (SNS) and renin angiotensin system (RAS) in cardiac hypertrophy. Haemodynamic studies were performed to evaluate the vasoconstriction responses of adrenoceptors (i.e. α1- and β1- adrenoceptors) and angiotensin II type 1 receptors (AT1) to understand the functional role of SNS and RAS respectively using the cardiac hypertrophic rat model.
Description
Keywords
Nervous , Protein