Role Of Cyclooxygenases In Zebrafish Oogenesis And Their Transcriptional Regulation By Peroxisome Proliferator Activated Receptor Gamma

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dc.contributor.authorKhare, Vani
dc.date.accessioned2018-12-12T03:13:46Z
dc.date.available2018-12-12T03:13:46Z
dc.date.issued2013-02
dc.description.abstractProstaglandins are required for the successful development and functioning of the female reproductive system in vertebrates. The synthesis of prostaglandin relies on the catalytic activities of two cyclooxygenase isoforms (COX-1 and COX-2). Various reports emphasize that both COX isoforms are essential for the production of prostaglandin during various stages of oogenesis, such as oocyte growth, maturation and ovulation. In comparison to COX-2, there is a paucity of knowledge on the role of COX-1, especially in oogenesis. At the same time, while COX-2 is a well established marker in ovulation, its function in growth and maturation of oocyte requires further exploration. This study, thereby, distinguishes the role of COX-1 and COX-2 during zebrafish oocyte growth and maturation, firstly by examining the mRNA expression of both the isoforms in these oocyte stages. An increase in zebrafish follicle COX-1 mRNA expression was observed as the oocytes develop and mature.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/7267
dc.language.isoenen_US
dc.publisherUniversiti Sains Malaysiaen_US
dc.subjectCyclooxygenases In Zebrafish Oogenesisen_US
dc.subjectPeroxisome Proliferator Activated Receptor Gammaen_US
dc.titleRole Of Cyclooxygenases In Zebrafish Oogenesis And Their Transcriptional Regulation By Peroxisome Proliferator Activated Receptor Gammaen_US
dc.typeThesisen_US
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