Predictive Factor(S) For Short Term Response To Corticosteroids Therapy In Adults With Immune Thrombocytopenia At HUSM
| dc.contributor.author | Mohammad, Nurashikin | |
| dc.date.accessioned | 2017-09-06T02:11:36Z | |
| dc.date.available | 2017-09-06T02:11:36Z | |
| dc.date.issued | 2015 | |
| dc.description.abstract | Introduction: Acute immune thrombocytopenia (ITP) is a common benign bleeding disorder of variable etiology characterised by isolated thrombocytopenia. Corticosteroids had been used generally for so many decades as first line therapy to adults with ITP, nonetheless markers predictive of the short term response to corticosteroids remain poorly defined. Hence, in this study we retrospectively evaluated whether clinical and laboratory findings before treatment could predict response to corticosteroids in adults ITP patients in HUSM. Methodology: This is a retrospective record review involving 232 ITP subjects who attended hematology care at HUSM day-care ward from January 2004 until December 2014. Relevant information on clinical characteristics and various prognostic factors was extracted from medical records and HUSM laboratory computer system. Results: Majority of patients were female and mean age at presentation was 35.8 years. Mean platelet counts 20.3 X 109 /L. Almost 60% of patients were asymptomatic despite their level of platelet. More than 90% patients received corticosteroids as first line treatment. More than two-thirds of patients (61.8%) had overall response at short-term review. In univariate analysis, factors include age, fever, INR, CRP, platelet, monocytes and monocytes counts and bleeding symptoms were significant for unfavorable outcome. Using backward logistic | en_US |
| dc.identifier.uri | http://hdl.handle.net/123456789/4469 | |
| dc.language.iso | en | en_US |
| dc.publisher | Universiti Sains Malaysia | en_US |
| dc.subject | Acute immune thrombocytopenia | en_US |
| dc.subject | isolated thrombocytopenia. | en_US |
| dc.title | Predictive Factor(S) For Short Term Response To Corticosteroids Therapy In Adults With Immune Thrombocytopenia At HUSM | en_US |
| dc.type | Thesis | en_US |
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