The role of monocytic microparticles (mMP) in endothelial cell function
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Date
2019
Authors
Azlan, Maryam
Journal Title
Journal ISSN
Volume Title
Publisher
Pusat Pengajian Sains Perubatan, Universiti Sains Malaysia
Abstract
Monocytic microparticles (mMP) are membrane-derived microvesicles released from activated or
apoptotic monocytes. Monocytic MP are associated with inflammation and may play important
role in endothelial cell function. The main aim of this study was to identify phenotypic profiles of
mMP derived from THP-1, unseparated monocytes, co14• monocytes and CD1 a• monocytes by
flow cytometry and to identify the role of mMP in endothelial cell activation. Monocytic MP derived
from unseparated monocytes, co14• monocytes and CD1a+ monocytes but not THP-1 showed
high expression of CD14 and CD16, secreted IL-113 and TNF-a and activated endothelial cells.
Taken together our findings suggest that mMP derived from different cell types exhibit different
phenotypes and functions. Future study of mMP is necessary to understand their mechanism of
action.
Description
Keywords
monocythic