Determination Of Prognostic Markers For Cervical Cancer
| dc.contributor.author | Ahmad, Rahmatul Wahida | |
| dc.date.accessioned | 2018-07-10T00:40:01Z | |
| dc.date.available | 2018-07-10T00:40:01Z | |
| dc.date.issued | 2008-03 | |
| dc.description.abstract | Biomolecular factors could possibly improve the prediction of prognosis and diagnosis in cancer. Understanding specific molecular pathways could possibly shed some light in improving therapeutic modalities so that the treatment plan can be modified to suit individual cases. Various markers including factor VIII related antigen (MVD), Cyclooxygenase-2 (COX-2), E-cadherin, human telomerase reverse transcriptase (hTERT) and insulin like growth factor receptor (IGF-R) have been shown to play important roles in carcinogenesis and in predicting the prognosis of cervical cancer. Proliferation of tumor cells is uncontrolled, excessive and requires less growth factor since tumor cells have aberrant expression of IGFR. However, tumor cells cannot grow more than 1-10mm3 unless it is vascularised through angiogenesis by the formation of microvessels. Furthermore high expression of COX-2 suppress apoptosis, promote angiogenesis and tumor invasion. Malignant tumor cells have high metastatic potential because the cells are less adherent to each other as a result of decreased expression of E-cadherin. Cancer cells also do not undergo replicative senescence during each cell division because the hTERT enzyme synthesizes new telomerase and prevent apoptosis. This retrospective study was done among normal cervix, cervical intraepithelial neoplasia (CIN) and squamous cell carcinoma (SCC) of cervix which have been histopathologically diagnosed from year 1998 to 2003 in HUSM. All samples were subjected to immunohistochemistry approach to quantify the microvessel density (MVD) and to estimate the percentage of the expression of COX-2, E-cadherin, hTERT and IGF-R. Our results revealed that there were significantly increased expression of MVD, COX-2, hTERT and IGF-R as the disease become more cancerous (p<0.001). However, decreased expression of E-cadherin were seen in SCC samples compared to normal and CIN samples (p<0.001). MVD expression has been shown to be the most related with all clinical and clinicopathological parameters including lymph node metastasis (p=0.005), parametrial involvement (p=0.003), vascular space involvement (p=0.004), deep stromal invasion (p=0.003) and tumor differentiation (p=0.002). While COX-2 protein expression showed a significant correlation with lymph node metastasis (p=0.006), parametrial involvement (p=0.004) and tumor differentiation status (p= 0.001). | en_US |
| dc.identifier.uri | http://hdl.handle.net/123456789/5892 | |
| dc.language.iso | en | en_US |
| dc.publisher | Universiti Sains Malaysia | en_US |
| dc.subject | Biomolecular factors could possibly improve the | en_US |
| dc.subject | prediction of prognosis and diagnosis in cancer | en_US |
| dc.title | Determination Of Prognostic Markers For Cervical Cancer | en_US |
| dc.type | Thesis | en_US |
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