A RANDOMISED CONTROLLED TRIAL OF MGSO4 THERAPY FOR 24 HOURS VERSUS EARLY CESSATION IN PATIENTS WITH SEVERE PREECLAMPSIA
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Date
2010-11
Authors
AFFENDI, YUNUS
Journal Title
Journal ISSN
Volume Title
Publisher
Pusat Pengajian Sains Perubatan Universiti Sains Malaysia
Abstract
Introduction:
Magnesium sulphate has been shown to be the optimal anticonvulsant in
preventing the recurrence of seizures in eclampsia and in seizure prophylaxis
in preeclampsia. Traditionally, seizure prophylaxis has been administered
before delivery and continued postpartum for an arbitrary time, usually 24
hours.
Objectives:
The primary objectives of this study were to evaluate the safety and
effectiveness of using clinical parameters to signal cessation of postpartum
magnesium sulphate therapy among patients with Severe Preeclampsia.
Methodology:
A randomized trial of postpartum magnesium sulphate therapy was conducted in
HRPZII, Kota Bharu and HUSM, Kubang Kerian from December 2009 to September
2010. The control group received 24 hours of therapy, and the intervention
group received therapy until fulfilled clinical criteria for discontinuation
of seizure prophylaxis. The Independent t test, Chi-square test, and Fisher’s
exact test were used for analysis of data. A probability value of <0.05 was
considered statistically significant.
Results:
There were 52 patients in the control group and 50 patients in the
intervention group. The intervention group had a significantly shorter
duration of therapy (p< 0.05). There were no differences in mean booking BMI,
weight on admission, systolic blood pressure and platelet level between two
groups. However there were significance differences in mean age of the
patients, delivery gestational age, diastolic blood pressure and uric acid
level between two groups. There was no patient in this study had eclampsia or
required the reinitiation of therapy.
Conclusions:
Clinical parameters can be used effectively and safe to shorten the duration
of postpartum magnesium sulphate therapy in patients with severe preeclampsia.
Description
Keywords
Obstetrics & Gynecology