Sago hydrogel as dressing for partial thickness wound in rabbits
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Date
2001-12
Authors
Md Nor, Mohd Tarmizi
Journal Title
Journal ISSN
Volume Title
Publisher
Universiti Sains Malaysia
Abstract
At present there are various wound dressing available. Occlusive dressing is believed to promote better wound as healing compared to dry dressing. However, all the occlusive dressings available are not produced locally. In an attempt to promote our local, The Malaysian Institute of Nuclear Technology (MINT) has come out with a sago starch based occlusive dressing.
The aims of this study are:
1. To assess whether locally produced hydrogel is useful as a wound dressing
2. To assess whether it has any advantages over conventional dressing
3. To determine tissue response and infection control properties of the locally produced hydrogel used as wound dressing infection in comparison with paraffin gauze dressing. Twelve healthy New Zealand rabbits were used based on 2 proportional sample
size calculation. The rabbit's were shaved at both flanks. One side was randomly
dressed with a single layer of Sago Hydrogel and the opposite side dressed with
three layers of paraffin gauze (JelonetĀ®). Wound inspection was done at day 4, 10,
14 and 21 postoperatively. Swabs for culture and biopsies were taken during
wound inspection. Clinically, the wound started to heal at day 10. Wound
inspection revealed no clinically significant difference between both types of
dressing. Histologically, proliferative cells (endothelial and fibroblast) were not significantly different. No morbidity was noted in both groups. At the initial stage,
more exudates were seen in wound covered with Sago Hydrogel dressing. All
wounds covered by both dressings were free from clinical infection.
Microbiologically, wound covered with Sago Hydrogel grew gram positive
organisms at an early stage, but at later time shifted to gram negative
microorganisms. This colonization did not cause any clinical infection. Sago
Hydogel dressing was easily peeled off. During removal of Sago Hyrogel dressing,
the animal did not require any extra analgesic.
In conclusion, Sago hydrogel dressing can be used as a conventional dressing
because there was no significance difference in histological (proliferative and
granulation tissue) changes and clinical wound healing. There was also no
evidence of clinical infection on the wounds, which were covered by Sago hydrogel
as compared to wound covered by conventional dressing.
Description
Keywords
Sago hydrogel