Molecular Cytogenetics Of Myelodysplastic Syndrome – Hospital Based Study
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Date
2014-07
Authors
Isa, Asmida
Journal Title
Journal ISSN
Volume Title
Publisher
Universiti Sains Malaysia
Abstract
Myelodysplastic Syndrome (MDS) is a haematological condition characterised by
hypercellular bone marrow and low peripheral blood counts. The objectives of this
study were to identify chromosomal aberration using conventional cytogenetics and
array comparative genomic hybridisation (array-CGH) in MDS patients and correlate
with its’ haematological findings. A total of 8 patients were recruited. Cytogenetic
results revealed six normal karyotypes, a karyotype with structural abnormalities
(del(5)(q13q33) and a karyotype with complex rearrangement (t(1;11), t(2;11),
del(4p), del(5p), del(9p)). By array-CGH technique, known cytogenetic aberrations,
complex chromosome aberrations and rare/cryptic aberrations (<5 Mb) were
detected. In the case of common aberrations, del5q (q13.1 - q13.2 (2.4 Mb)) and
large amplification of chromosome 8 (p23.3-p11.1 (46.3 Mb) and q11.1-q24.3
(98.7 Mb)) were detected. In complex aberrations, the aberrations involved from
0.7 Mb to 98.7 Mb in size. These patients showed similarities of haematological
findings. Five cryptic aberrations were identified in 3 patients (0.7 Mb to 4.8 Mb).
As a conclusion, common, complex and cryptic aberrations were detected in MDS
patients. The associated haematological findings could provide useful information to
stratify the suitability of the treatments for the patients. These findings also might
contribute to the heterogeneity of choromosomal aberrations in MDS patients.
Description
Keywords
Molecular cytogenetics of , myelodysplastic syndrome