F8 a prospective, randomized, double-blinded trial to study the efficacy of topical tocotrienol in the prevention of hypertrophic scars

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dc.contributor.authorKhoo Teng, Lye
dc.date.accessioned2022-08-15T08:04:46Z
dc.date.available2022-08-15T08:04:46Z
dc.date.issued2010
dc.description.abstractDespite widespread beliefs regarding the use of topical tocotrienol in the prevention of hypertrophic scars, there is very little evidence from well-controlled and randomized clinical trials to justify its benefits for surgical scars. Objective: The present study was conducted to evaluate the efficacy of topical tocotrienol in preventing the development of hypertrophic scars. Methods: A prospective, randomized, double-blinded study was performed in which the patients were randomized into either treatment group with 5% topical tocotrienol or a placebo group. The patients were required to apply the preparation to their scars twice a day for six weeks starting at two weeks after surgery. An evaluation of the scars was performed at weeks 0, 2, 6 and 16 following the onset of topical application using three methods: a clinical assessment using the Patient and Observer Scar Assessment Scale (POSAS), a photographic scar assessment by two independent assessors using a visual analogue scale, and laser Doppler imaging (LDI). Results: There was no statistically significant difference in scar parameters between the tocotrienol group (n=43) and the placebo group (n=40) in the POSAS, photographic scar assessment or mean flux of LDI (p>0.05). The mean LDI flux showed decreasing trend over time, which was positively correlated with the vascularity score (correlation coefficient=0.322) of observer scar assessment scale on week 0 (p=0.018) and total score of the patient scar assessment scale on week 6 (correlation coefficient=0.354, p=0.009). No significant adverse effects were observed. Conclusions: Twice daily application of 5% topical tocotrienol had no significant effect on the appearance and perfusion of scars over four months post-surgery. LDI has a promising role as a scar assessment tool.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/15835
dc.publisherPusat Pengajian Sains Perubatanen_US
dc.subjectTopical tocotrienol in the preventionen_US
dc.titleF8 a prospective, randomized, double-blinded trial to study the efficacy of topical tocotrienol in the prevention of hypertrophic scarsen_US
dc.typeArticleen_US
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