Study Of Cytotoxic Mechanism And The Role Of Microrna In MDA-MB-231 Cell Lines Treated With Phaleria Macrocarpa (Boerl.) Fruit Ethyl Acetate Fraction (PMEAF)

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dc.contributor.authorNowroji, Kavitha
dc.date.accessioned2020-10-28T06:32:13Z
dc.date.available2020-10-28T06:32:13Z
dc.date.issued2017-12
dc.description.abstractPhaleria macrocarpa is a well-known medicinal plant which exhibited cytotoxicity against various cancerous cells. The objective of this study was to determine the in vitro cytotoxicity effect by biochemical assay through the regulation of miRNAs on MDA-MB-231 treated with Phaleria macrocarpa ethyl acetate fraction (PMEAF). Total phenolic content of PMEAF was expressed as 14.91 ± 0.97 mg GAE/g. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and CyQuant Cell Proliferation assay results indicated that PMEAF is a potential anticancer agent with the average IC50 values of 18.10 μg/mL.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/10654
dc.language.isoenen_US
dc.publisherUniversiti Sains Malaysiaen_US
dc.subjectCytotoxic Mechanismen_US
dc.subjectThe Role Of Micrornaen_US
dc.subjectMda-Mb-231 Cell Linesen_US
dc.subjectPhaleria Macrocarpa (Boerl.)en_US
dc.subjectFruit Ethyl Acetate Fraction (Pmeaf)en_US
dc.titleStudy Of Cytotoxic Mechanism And The Role Of Microrna In MDA-MB-231 Cell Lines Treated With Phaleria Macrocarpa (Boerl.) Fruit Ethyl Acetate Fraction (PMEAF)en_US
dc.typeThesisen_US
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