Cervical smear at antenatal booking in HUSM : is it worthwhile?
| dc.contributor.author | Syed Zainol Abidin, Sharifah Sofiah | |
| dc.date.accessioned | 2017-08-21T09:13:02Z | |
| dc.date.available | 2017-08-21T09:13:02Z | |
| dc.date.issued | 2001-05 | |
| dc.description.abstract | The study is aimed to determine the prevalence of abnormal cervical smear in pregnant women attending booking clinic at Hospital Universiti Sains Malaysia. Secondly, we aimed to determine the pregnancy-related physiologic changes associated with normal cytological cervical smear in the study population. Lastly, we planned to compare the cytological cervical smears between pregnant and non-pregnant women in Hospital Universiti Sains Malaysia. It is a prospective cross-sectional study, was carried out at the Hospital Universiti Sains Malaysia (HUSM), Kubang Kerian, Kelantan between July 1999 till June 2000. A total of 321 pregnant women agreed to participate after counseling and verbal consent was obtained. From 321 cervical smears collected, 310 (96.6%) were satisfactory smears and 11 (3.4%) were unsatisfactory. The detail results of satisfactory smear, normal smear were 55 (17.7%), non-specific inflammatory smear were 193 (62.3%), infection of Gardnerella were 4 (1.3%), Actinomyces infection was 1 (0.3%), Trichomonas vagina/is infection was 1 (0.3%), Candidiasis infection were 45 (14.5%), ASCUS were 5 (1.6%), AGUS were 3 (1.0%), LSIL (HPV & CIN I) were 3 (1.0%) and no HSIL or carcinoma. From the study, the pregnancy-related changes associated with normal cervical smears in the study population consist of 285 (91.9°/o) navicular cells, 308 (99.3o/o) Lactobacilli, 207 (66.8°/o) squamous metaplastic cells, 3 ( 1.0%) decidual cells and no trophoblastic cells or "Arias-stella" changes cells. Navicular cells and abundant lactobacilli are characteristic of pregnancy-related changes in the cervical smear that are commonly seen. Decidual cells, trophoblastic cells or "Arias-stella" cells are rarely seen In pregnancy. When comparing the cervical smear of pregnant women with the cervical smear of non-pregnant women, the results were statistically not significant at p-value <0.05 for normal smear, non-specific inflammatory smear, Gardnerella vagina/is infection, Actinomyces infection, Chlamydia infection, ASCUS, AGUS, LSIL, HSIL, Squamous cell carcinoma and adenocarcinoma of the cervix. The result was statistically significant at p-value <0.05 for candida infection. Candida infection is more prevalent in pregnant women. In non-pregnant population, we are able to detect more abnormal cervical smears such as LSIL (2.0%), HSIL (1.1 %), Squamous cell carcinoma (0.3%) and adenocarcinoma of the cervix (0.3%). This is probably because the samples are larger, a total of 831 cervical smears. We conclude that we are able to detect abnormal cervical smears, whether the smears are taken during pregnancy or non-pregnant state and larger samples are required in pregnant population to get statistically significant results. Physiological pregnancy-related changes that may be present in the cervical smears such as decidual cells, trophoblastic cells or "Arias-stella" changes cell which can mimic malignant cells are rarely seen in pregnant population and we can differentiate the cells with meticulous and expert interpretation of the smears by the cytopathologist. | en_US |
| dc.identifier.uri | http://hdl.handle.net/123456789/4399 | |
| dc.language.iso | en | en_US |
| dc.publisher | Universiti Sains Malaysia | en_US |
| dc.subject | Cytological cervical smear | en_US |
| dc.title | Cervical smear at antenatal booking in HUSM : is it worthwhile? | en_US |
| dc.type | Thesis | en_US |
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