Effects Of Nigella Sativa On Indicators Of Recovery Following Exercise-Induced Muscle Damage (Eimd) As A Model Of Inflammation
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Date
2016-04
Authors
Raimi, Nur Fatihah
Journal Title
Journal ISSN
Volume Title
Publisher
Universiti Sains Malaysia
Abstract
Unaccustomed, intense exercise is associated with delayed onset muscle soreness
(DOMS), a symptom of exercise-induced muscle damage (EIMD). As EIMD induce
inflammation to muscles, Nigella sativa (NS) was seen as a potential natural remedy
to cure inflammatory problems to replace non-steroidal anti-inflammatory drugs
(NSAIDs), which are believed to share certain unwanted effects on gastrointestinal
and respiratory tract, kidneys, cardiovascular and liver. This study examined the
effectiveness of NS in attenuating EIMD as a model of inflammation, and
determined the effective dosage of NS to increase the speed of recovery following
EIMD. Subjects (n=33) were assigned to three groups based on the doses of NS,
which were either NS 3000mg, NS 1500mg or placebo. They had underwent 10 sets
of 10 repetitions of counter-movement jump (CMJ) with 30 second intermittent rest
between set, adopting a squat stance in starting and landing position to induce muscle
damage. A set of tests were conducted to measure muscular power, soreness,
tenderness, thigh circumference, range of motion (ROM), serum creatine kinase (CK)
and lactate dehydrogenase (LDH) at pre-exercise, 30 minutes, one day, two days,
three days and four days post-exercise. Right after the exercise bout, a single one-off
dose of NS (either 3000mg or 1500mg) or placebo was administered. As expected,
exercise conducted decreased muscular power (post 30 min to 1 day) (P<0.05) and
ROM (post 30 min to 1 day) (P<0.05), and increased soreness (post 30 min to 1 day)
(P<0.05), tenderness (post 30 min to 1 day) (P<0.05), thigh circumference (post 30
min to 1 day) (P<0.05), CK (post 30 min to 1 day) (P<0.05), and LDH (post 30 min
to 1 day) (P<0.05). Findings in all parameters related to EIMD suggested that CMJ
protocol used in this study was sufficient to induce muscle damage. However, no
significant interaction was found on all measured parameters on three different
groups across the measurement sessions (P>0.05). The effective dosage of NS to
increase the recovery speed was unable to be determined because regardless the dose
of NS given, a single one-off intake is of no significant benefit to increase the speed
of recovery following EIMD. These results did not support the hypothesis that
ingestion of NS would attenuate EIMD, and the intake of NS in a single one-off
method might be the possible cause.
Description
Keywords
Effects of nigella sativa , on indicators of Recovery.