Predicting Gentamicin Induced Nephrotoxicity Using Pharmacometabonomic Approach

dc.contributor.author	Aziz, Fatimatuzzahra’ Abd.
dc.date.accessioned	2021-02-18T07:50:23Z
dc.date.available	2021-02-18T07:50:23Z
dc.date.issued	2019-03
dc.description.abstract	Gentamicin has been one of the most widely used antibiotics. However, its nephrotoxicity is a major concern as it is filtered through the kidneys for excretion in the form of urine. However, early diagnosis is difficult and no reliable metabolites as biomarkers are currently available. Thus, in this study, a pharmacometabonomic approach using nuclear magnetic resonance (NMR) spectroscopy to investigate the altered metabolic pattern in serum and urine samples prior to administration of gentamicin has been employed to develop a model to predict nephrotoxicity induced by gentamicin and to identify the metabolic biomarkers associated. The aim of this study is therefore to determine the potential of urine and serum metabolites in predicting gentamicin induced nephrotoxicity	en_US
dc.identifier.uri	http://hdl.handle.net/123456789/11366
dc.language.iso	en	en_US
dc.publisher	Universiti Sains Malaysia	en_US
dc.subject	Predicting Gentamicin Induced Nephrotoxicity	en_US
dc.subject	Pharmacometabonomic Approach	en_US
dc.title	Predicting Gentamicin Induced Nephrotoxicity Using Pharmacometabonomic Approach	en_US
dc.type	Thesis	en_US

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