Effect of exogenously administered hydrogen sulphide (H2S) on plasma concentration of nuclear factor-KAPPA B (NF-kB) and intercellular adhesion molecule-1 (ICAM-1) IN A rat model of renal ischemia reperfusion injury.
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Date
2017-03
Authors
Hashmi, Syed Fayaz Ul Haq
Journal Title
Journal ISSN
Volume Title
Publisher
Universiti Sains Malaysia
Abstract
Kajian ini menyelidik kesan pemberian penderma hidrogen sulfida (H2S), sodium hidrosulphida (NaHS) secara eksogenous ke atas kepekatan nuklear faktor kappa-B (NF-kB) dan molekul-1 intersel (ICAM-1) dalam kecederaan iskemia reperfusi ginjal di dalam tikus normotensif Wistar Kyoto (WKY) tanpa kegagalan ginjal (NRF) dan dengan kegagalan ginjal (RF) serta hipertensi aruhan L-nitro-arginin-methil-ester (L-NAME) di dalam tikus tanpa kegagalan ginjal (NRF) dan dengan kegagalan ginjal (NRF).
The present study investigated the effect of exogenous administration of hydrogen sulphide (H2S) donor, sodium hydrosulphide (NaHS) on the concentration of nuclear factor kappa-B (NF-kB) and inter cellular adhesion molecule-1 (ICAM-1) in renal ischemia reperfusion injury in normotensive Wistar Kyoto (WKY) non-renal failure (NRF) and renal failure (RF) rats as well as L-nitro-arginine-methyl-ester (L-NAME) induced hypertensive NRF and RF rats.
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Keywords
Hydrogen , plasma concentration