Correlation of interleukin 31 serum levels in patients with atopic dermatitis, allergic rhinitis and atopic asthma

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dc.contributor.authorMohd @ Muhammad Amin, Siti Noor Syuhada
dc.date.accessioned2017-09-07T04:32:58Z
dc.date.available2017-09-07T04:32:58Z
dc.date.issued2013-07
dc.description.abstractInterleukin 31 (IL-31), is one of the cytokines which appears to be an important regulator of TH2 responses. Previous study has been done by Zhang et al. (2008), to determine IL-31 serums levels in atopic dermatitis (AD). However, the serum levels of IL-31 in allergic rhinitis (AR) and atopic asthma (AA) is still unclear. The objectives of this cross sectional study are to determine IL-31 serum levels in AD, AR and AA, to study the association between IL-31 and predisposing factors with allergic diseases, to correlate IL-31 levels and the severity of allergic diseases and to compare IL-31 levels and pruritus in patients with allergic diseases. This study involved 70 patients with AD from the skin clinic of Hospital Universiti Sains Malaysia (HUSM) and Hospital Raja Perempuan Zainab II (HRPZ II), 70 patients with AR from the Ear, Nose and Throat Clinic (ENT clinic) of HUSM, 70 patients with AA from the Chest Clinic and Pediatrics Clinic of HUSM and 70 healthy controls (staff and people of HUSM). Five milliliters of blood were withdrawn and centrifuged for 5 minutes at 2000 rpm to obtain the serum and analyzed for IL-31 levels by using enzyme-linked immunosorbent (ELISA) kits (Human IL-31 Duoset, R&D System). Independent t-test was the statistical method used to compare IL-31 levels between healthy controls and allergic diseases as well as IL-31 levels and pruritus in allergy. Simple and multiple logistic regressions were used to analyze the association. Kruskal Wallis test was used to determine IL-31 levels and the severity of AD and AA and Mann-Whitney test was used to determine IL-31 and the severity of AR. The results showed that there was no statistically significant difference of mean (SD) of IL-31 levels among diseases, 5048.79 (24628.27) and controls, 2195.55 (9016.57) (p=0.344). The levels of IL-31 and other predisposing factors showed significant associations in smoking status, occupational exposure and area of living for AD and AR, however in AA, the significant association only found in smoking status and occupational exposure. There was no significant difference between IL-31 levels and the severity of allergic diseases, AD (p=0.104), AR (p=0.245) and AA (p=0.745). The results showed there was no significant differences between IL-31 levels and pruritus in patients with mean (SD) in pruritic, 6168.25 (30552.07) and non-pruritic, 3693.64 (14600.99).en_US
dc.identifier.urihttp://hdl.handle.net/123456789/4514
dc.language.isoenen_US
dc.publisherUniversiti Sains Malaysiaen_US
dc.subjectInterleukin 31 (IL-31), allergic rhinitis (AR) and atopic asthma (AA)en_US
dc.titleCorrelation of interleukin 31 serum levels in patients with atopic dermatitis, allergic rhinitis and atopic asthmaen_US
dc.typeThesisen_US
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