The Effectiveness Of Oral Appliance In Comparison With Continuous Positive Airway Pressure In The Treatment Of Obstructive Sleep Apnoea: A Randomised Clinical Trial
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Date
2016-02
Authors
Elsherbiny, Momen Zaky Elsayed
Journal Title
Journal ISSN
Volume Title
Publisher
Universiti Sains Malaysia
Abstract
A parallel design randomised controlled trial was conducted at the Advanced Medical and Dental Institute (AMDI) Universiti Sains Malaysia (USM) to determine the effectiveness of oral appliances (OA) in comparison to the continuous positive airway pressure (CPAP) in the treatment of obstructive sleep apnoea. Patients referred from the Ear, Nose and Throat clinic were screened for eligibility to participate in the trial. After considering all the inclusion and exclusion criteria, 40 patients were recruited and were randomised by an online randomization software available on (www.randomization.com) which was used to produce a randomization plan. This trial was blinded and patients were randomised into two groups by a nurse opening a sealed envelope that had been prepared earlier by the researcher which contained either the letter A or B. As a result 19 patients in the CPAP group and 21 patients in the OA group were recruited. However, 1 patient from each group did not continue the trial, leaving only 38 study participants in total, 18 patients in the CPAP group and 20 patients in the OA group. The trial period was one month. Apnoea/Hypopnea index (AHI), minimum nocturnal oxygen saturation (MinO2) and mean oxygen saturation (MeanO2) were recorded before and after treatment for patients in both groups by overnight polysomnography. Epworth Sleepiness Scale
(ESS) and the Malay version of Calgary Sleep Apnoea Quality of Life Index (SAQLI) were given to the patients before and after treatment to assess the changes in patient’s daytime sleepiness and health-related quality of life respectively.
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Keywords
The effectiveness of oral appliance in comparison , obstructive sleep apnoea