Association of degree of expression of ki 67 proliferative cell marker with aggressive giant cell tumor of the bone.
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Date
2013
Authors
Wan Faisham Nu Man, Wan Ismail
Journal Title
Journal ISSN
Volume Title
Publisher
Pusat Pengajian Sains Perubatan
Abstract
Stag11 Ill Campanacci giant cell tumour of· the bone always exhibits high biological aggressiveness and has tendency for local recurrenc11s and pulmonary metastases. We analyzed Ki-67 immuno-histochemistry of 31 cases of stage Ill giant cell tumour of the bone to determine the clinico-pathological correlation. The mean value of Ki-67 index obtained as a percentage of 1000 background cells was 8. 15 with range from 1. 00 to 20. 00. There was no difference of indices in cases with r11currence and pulmonary metastasis. In conclusion, Ki-67 index is not useful as a prognostic marker for aggressive typ.e of giant cell tumour of the bone.
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Keywords
Campanacci giant cell tumour of· the bone always exhibits high biological aggressiveness and has tendency for local recurrenc11s and pulmonary metastases.