Fundamental studies on the mechanism of action of a novel sirtuin inhibitor (BZD9L 1) in colorectal cancer cells- towards the elucidation of a novel cancer therapeutic agent.
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Date
2016
Authors
Chern Ein, Oon
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Abstract
Gemcitabine remains the standard treatment for pancreatic cancer. although most patients acquire
resistance to the therapy. Up-regulated in pancreatic cancer. SIRTI is involved in tumorigenesis and drug
resistance, However the mechanism through which SIRTl regulates drug sensitivity in cancer cells is
mainly unknown.
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Keywords
novel sirtuin inhibitor , cancer therapeutic