Erythrocyte sodium fluxes; intracellular . magnesium calcium and serum electrolytes in diabetes with pregnancy induce: hyi3ertension
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Date
1995-07
Authors
Larmie, E.T.
Journal Title
Journal ISSN
Volume Title
Publisher
Pusat Pengajian Sains Perubatan, Universiti Sains Malaysia
Abstract
Serum concentrations of sodium, potassium, ionised calcium, toted calcium,
magnesium and erythrocyte sodium efflux rate constants were deternuned
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spectrophotometricall~ and With 22 Na respectively in normotensive pre~nant
i women (NP), normotersive pregnant womeh With diabetes m~llitus (Ofj), wotnen
with diabetes msllitys and ~regn~ncy-itlduced hypertehsioh (DP-f:'IH) and
women With pregnane 'nduc~J hyp~rtensioh (Nf:»-PIH) ~uring the third trimester
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of pregnancy. No sig ificant diheten¢es were evident In: serum total rrlE:t~nesium
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sodium, potassium, a d lot1ised calci~m or ~rythrocyte hlagtiesium bstween the
four groups. Serum t~tf=!l calcium, hbWSver, was Significantly (p<0.05) lower in
NP-PIH women and ~tH women with diabetes mellitus. The cause for the lower
serum total calcium iJ diabetic ahd hor1-diab9tic PIH women is hot evident but
appears independent ~t the diabetes.
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Erythrocyte mean total• sodium efflUx tate constant was significantly (p < 0.01)
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higher in NP-PIH women. However, the mean ouabain-Insensitive sodium efflux
rate constant was sligHtly higher in OP women. When compared to the other
three groups.
Mean ouabain-sensitive sodium efflux rate constant Was significantly (fl< 0.01; P
< 0.05) higher in NP-fJIH and DP-PIH respectively.
It would appear that while pre9nar1cy-induced hypertension increases the Na+,
K+ -AT pase pump activity, this effect is moderated In the presence of a
preexistin9 diabetes niellitus.
Description
Keywords
pregnancy