Comparison of retinal nerve fiber layer and macular thickness in Malay children with and without strabismus
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Date
2014
Authors
Koh, Alisa Victoria
Journal Title
Journal ISSN
Volume Title
Publisher
Universiti Sains Malaysia
Abstract
Introduction: Optical coherence tomography (OCT) has been widely used globally to study the retinal nerve fiber layer thickness (RNFLT) and macular thickness (MT) in patients with strabismus and strabismic amblyopia of different ethnicities. There are o similar published literature found involving patients of Malay ethinicity.
Objective: To compare the mean RNFLT and MT between Malay children with and without strabismus and strabismic Malay children with and without amblyopia.
Methodology: A prospective, comparative cross sectional study was conducted in Ophthalmology Clinic, Hospital Universiti Sains Malaysia from February 2012 to January 2014. A total of 136 Malay children aged 3 to 16 years were recruited for this study; 68 each in strabismus and without stabismus (normal) group. Strabismic children were subgrouped into 17 in strabismus with amblyopia and 51 in strabismus without amblyopia group. A comprehensive ocular examination which included orthoptic assessment, cycloplegic refraction, intraocular pressure measurement, anterior segment and dilated fundus examination was performed. The mean RNFLT and MT were measured using the Cirrus HD-OCT.
Result: The mean average RNFLT in Malay children with strabismus [97.04(11.99) μm] was significantly thinner as compared to normal Malay children [101.10(9.04) μm], p = 0.02. The superior quadrant RNFLT was also significantly thinner in the strabismus group as compared to normal group (p = 0.041). The mean average MT was 277.23(15.53) μm and 282.38(10.46) μm in the strabismus and normal groups,
respectively, reaching statistically significant difference (p = 0.025). The means of superior outer MT (p = 0.049), superior inner MT (p = 0.019), inferior inner MT (p = 0.028) and nasal inner MT (p = 0.023) were significantly thinner in Malay children with strabismus as compared to normal Malay children. There were no significant differences of mean RNFLT and MT between strabismic Malay children with and without amblyopia (p > 0.05).
Conclusion: Malay children with strabismus have thinner RNFLT and MT than normal orthophoric Malay children. The mean RNFLT and MT are comparable between strabismic Malay children with and without amblyopia.
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Keywords
Optical coherence tomography (OCT), retinal nerve fiber layer thickness (RNFLT) and macular thickness (MT)