Effects Of Nigella sativa, Linoleic Acid And Eurycoma longifolia On Rabbit Penile Erection

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dc.contributor.authorSahdom, Rosmiyani
dc.date.accessioned2019-05-02T06:57:41Z
dc.date.available2019-05-02T06:57:41Z
dc.date.issued2018-03
dc.description.abstractThe Nigella sativa (NS) and Eurycoma longifolia (EL) not plays role in fertility but gastroprotective, anti-tumor, anti-anxiety, anti-microbial, anti-inflammatory, antiparasitic, anti-oxidant and anti-pyretic activities. No previous has thorough investigation on both medicinal plants giving spontaneous erection in penis, while studies claim on their potential as well as their effectiveness on reproduction system. Thus, this study investigated these plant’s effect on penile erection of rabbit. In Nigella sativa treatment, animal was treated with Nigella sativa oil , Nigella sativa microemulsion and Nigella sativa nanoemulsion (NSN) and Eurycoma longifolia (EL). Nigella sativa were administered freshly to the rabbits cause no stability assessment done for this preparation. The determination of oil/water Nigella sativa emulsion drug particles size was done, mainly because intravenous introduction. Data expressed the NSN is effective formulation compared to NSO and NSM with longer duration in erection of penis. Although, EL alone shown greater erection when given alone in comparing with positive PDE-5 inhibitor sildenafil. NSN also appear decrease the systemic arterial pressure in the present of vasodilation activity but not adversely. NSN give significant increase (p<0.05) in both alone and in the present of sodium nitroprusside (SNP) while EL alone showed no changes in erection in present of SNP and NG-nitro-L-arginine monomethyl ester (L-NAME). NSN possibly have its own independent mechanism in erection. In other hand, both agents, show immediate respond after 5 minutes oral administration of NSN (30 mg/kg), EL (0.1 mg/kg) for both extraction of 50:50 and 100:0. The results of the present study support the hypothesis that both Nigella sativa and Eurycoma longifolia has potential to induce immediate respond in erection of penile and greater improvement in length as well as duration of erection. Further study on mechanism of both agents on penile erection also need to be elucidate.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/8133
dc.language.isoenen_US
dc.publisherUniversiti Sains Malaysiaen_US
dc.subjectEffects of Nigella sativa, Linoleic Aciden_US
dc.subjecton rabbit penile erectionen_US
dc.titleEffects Of Nigella sativa, Linoleic Acid And Eurycoma longifolia On Rabbit Penile Erectionen_US
dc.typeThesisen_US
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