Assessment Of Radioiodine Clearance In Differentiated Thyroid Cancer Patients In Hospital Kuala Lumpur

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dc.contributor.authorRosdi, Abdullah Hanif
dc.date.accessioned2019-07-12T00:38:50Z
dc.date.available2019-07-12T00:38:50Z
dc.date.issued2018
dc.description.abstractRadioiodine treatment has long been used since 1950’s for the treatment of various malignancy and non-malignancy diseases. It was the most popular, widely used, effective and safe unsealed source of radionuclide therapy. However, due to high gamma energy emitted from it which may induce stochastic effect to the public, radiation regulation has been introduced. Different countries have their own regulation regarding period of hospitalization needed before patient can be released to the public. Atomic Energy Licensing Act 1984 (Act 304) has stated that patient shall be discharged from isolation once the external dose rate falls below 50μSv/H which is equal to retained body activity of 1100MBq. To assess the appropriate isolation period of radioactive iodinated thyroid cancer patients in Hospital Kuala Lumpur. Differentiated thyroid cancer patients referred for radioactive iodine treatment were recruited in this study. Total participants were 170 and divided into 4 groups based on I-131 doses given (80mCi, 100mCi, 120mCi and 150mCi). External dose rate was measured at 6, 18, 24, 48 and 72 hours after ingestion of I-131 using ionising chamber survey meter. Graph of radioactivity versus time was plotted and clinical data was analysed using IBM SPSS software. Mean effective half-life of I-131 is 14.57±1.03 hours which is equal to 14 hours and 34 minutes. Initial dose of I-131 and gender had significantly influenced iodine clearance with p value of 0.006 and <0.001 respectively. Conversely, the types of thyroid cancer, races and age do not have significant impact on iodine clearance. One hundred and sixty seven out of 170 patients (98.2%) had radiation level below 50μSv at 48 hours. Ideal isolation period for I-131 treatment for thyroid cancer patient with normal renal function in Hospital Kuala Lumpur regardless of ethnics, iodine doses, gender and ages is 48 hours.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/8467
dc.language.isoenen_US
dc.publisherUniversiti Sains Malaysiaen_US
dc.subjectDifferentiated thyroid carcinoma, iodine-131, effective half-lifeen_US
dc.subjectpatient discharge, external dose rate, radiation safetyen_US
dc.titleAssessment Of Radioiodine Clearance In Differentiated Thyroid Cancer Patients In Hospital Kuala Lumpuren_US
dc.typeThesisen_US
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