MR VOLUMETRY STUDY OF HIPPOCAMPUS AND TEMPORAL LOBE IN MALAY ADULTS WITH NORMAL MRI BRAIN IN HUSM
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Date
2011-05
Authors
ROZIAH, DALI
Journal Title
Journal ISSN
Volume Title
Publisher
Pusat Pengajian Sains Perubatan Universiti Sains Malaysia
Abstract
Introduction: Volumetry of hippocampus and temporal lobe has been paid
attention more and more along with advanced in MRI. Magnetic resonance imaging
(MRI) is a non-invasive and provides detailed, accurate morphology of hippocampus
and also temporal lobe. MR volumetry of these two structures is important as they are
affected by several disease processes. Establishing a normative data for a population is
essential so as to refer and diagnose particular illness. There are computer aided
automated and semi-automated method available for MR volumetry. This study used
manual method for the normative data of hippocampus and temporal lobe.
Volumetric MRI analysis is more sensitive than T2-weighted imaging to atrophy
associated with hippocampal sclerosis. It also distinguish volume loss from space
occupying lesion as well as may predict a good prognosis following surgery for
epilepsy (Bronen, Cheung et al. 1991).
The purpose of this study is to obtain hippocampal and temporal lobes volumes in
normal Malay adults as a normative database. Hence, it can be a reference in
diagnosing diseases related with these two structures.
Objectives: The aims of this study is to determine the volume of hippocampus
and temporal lobe in Malay adult with normal MRI brain.
Methods and materials: This was a cross sectional observational study to
determine volume of hippocampus and temporal lobe in Malay adult with normal MRI
brain. The age of the patients was range from 21 to 49 years old. The study period was
from February 2008 until June 2009 and 51 subjects were included. Majority of them
were normal volunteers, and some were patients who had normal MRI brain. MRI of
brain and temporal lobe series were performed using a Signa Horizon LX 1.0 Tesla
from the Generic Electric Company. Oblique coronal sections perpendicular to the axis
of hippocampus were done with 4mm slice thickness and 1mm gap. T1, T2, FLAIR and
SPGR series were done. Hippocampal and temporal lobevolumetry were performed.
The mean and standard deviation (SD) of hippocampus and temporal lobe volume were
calculated using SPSS version 17.
Results: Mean and standard deviation of the total hippocampus volume of
normal adult was 6.43 cm3 (0.80) for all subjects. Mean total hippocampus volume was
6.62 cm3 (0.87) in male and 6.27 cm3 (0.71) for female. Mean and standard deviation of
hippocampus were 3.35 cm3 (0.46) on the right and 3.01 cm3 (0.45) on the left side.
Mean hippocampal volume for the right side for male subjects is ranging from 3.21 cm3
(0.44) to 3.54 cm3 (0.35) and for the left side is from 2.95 cm3 (0.30) to 3.32 cm3
(0.42). Mean hippocampal volume for the right side for female subjects is ranging from
3.07 cm3 (0.47) to 3.42 cm3 (0.30) and for the left side is from 2.80 cm3 (0.36) to 3.08
cm3 (0.25).
Mean total temporal lobe volume for all subjects was 161.28 cm3 (19.48). Mean total
temporal lobe volume for male and female were 169.23 cm³ (19.40) and 153.63 cm³
(16.54) respectively. Mean temporal lobe volume for the right side is ranging from
79.18 cm³ (8.25) to 87.25 cm³ (11.11) and for the left side is from 76.79 cm³ (9.42) to
84.55 cm³ (11.04).
There was significant correlation between volume of hippocampus and volume of
temporal lobe (r = 0.475, p < 0.01).
Conclusion: These normative data for hippocampus and temporal lobe were
useful reference for Malay population. There was significantly larger right
hippocampus as compared to left hippocampal volume. There is fairly good association
between the temporal lobe and hippocampal volume within normal adult with normal
MRI brain.
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Keywords
Radiology