Comparison of dry eyes parameters in postmenopausal women with and without honey supplement
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Date
2017
Authors
Baharuddin, Noorlaila
Journal Title
Journal ISSN
Volume Title
Publisher
Pusat Pengajian Sains Perubatan, Universiti Sains Malaysia
Abstract
Background
Dry eyes is one of the most common ocular surface problems among elderly particularly
among postmenopausal women due to hormonal imbalance. Ocular surface inflammation and
tears hyperosmolarity are known pathogenesis of dry eyes.
Objective
The objective of this study is to compare the mean change (baseline and three months post
treatment) in symptom [base on Ocular Surface Disease Index (OSDI) score] and signs
(Schirmer test value and TBUT) between oral supplementation of honey cocktail and nonhoney
groups among postmenopausal women.
Methods
A randomised interventional study was conducted from November 2015 to May 2017, at
Hospital Universiti Sains Malaysia, Kelantan, Malaysia. The eligible postmenopausal women
were randomised into 2 groups (honey cocktail group and non-honey group) by using random
sampling envelope technique. Participants were assessed for OSDI score using OSDI
questionnaire and evaluated for Schirmer test value and TBUT at baseline and at 3 months
after daily oral supplementation of 20g honey cocktail. Statistical analyses were performed
using SPSS version 22.0. Only right eye was chosen to analyse for standardization.Results
A total of 60 postmenopausal women were recruited (30 participants in honey cocktail group
and 30 participants in non-honey group). Honey cocktail group showed reduction of
disability of OSDI score and improvement in Schirmer test value at 3 months post honey
supplementation compared to non-honey group. There was no significant difference in mean
change of OSDI score (p=0.644), Schirmer test value (p=0.372) and TBUT (p=0.471)
between honey cocktail and non-honey groups.
Conclusion
Postmenopausal women with honey cocktail supplements shows better clinical response
compared to non-honey group. However, there was no significant difference between the two
groups. Further studies with longer duration of honey supplementation is recommended as
honey have a slow effect. Oxidative stress and inflammatory markers are essential to
establish the effect of honey supplements in postmenopausal women.
Description
Keywords
Dry eye syndromes