STUDIES ON SIDE EFFECT PROFILE OF TREATED HYPERTENSIVES ON SELECTED PHARMACOTHERAPY
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Date
2001
Authors
MARINA, ISMAIL
Journal Title
Journal ISSN
Volume Title
Publisher
Pusat Pengajian Sains Perubatan Universiti Sains Malaysia
Abstract
Hypertension is a major public health problem because of its
consequences. Its treatment is crucial and goals include to decrease ~orbidity
and mortality associated with hypertension by decreaSing blood pressure using
drugs that have good tolerance, dosing convenience and low cost. As many
antihypertensives are now available, it is important to choose the most
appropriate drug in terms of efficacy and with least side effect in order to
improve compliance and the patient's quality of life. In HUSM, metoprolol is a
widely used. Its metabolism is mediated by the polymorphic debrisoquinehydroxylase
that exhibits large inter ethnic difference. As most of its adverse
reactions could be due to excessive plasma concentrations, its use among our
local population may therefore be associated with adverse effects due to reduced
capacity of the local population to metabolise the drug. The objedives of this
study were therefore to investigate the use of metoprolol in the treatment of
hypertension in relation to the incidence of adverse drug reactions it caused. We
would also determine whether patients who experienced adverse reactions
suffered reduced quality of life. As controls, we used patients who received
enalapril or enalapril combined with metoprolol in the treatment of their
hypertension.
Description
Keywords
Internal Medicine