Preparation And Characterization Of Collagen Grafted Poly(Dimethyl Siloxane) Modified Films For Skin Substitute Applications
| dc.contributor.author | Rezaei Darvishi, Seyed Mahmood | |
| dc.date.accessioned | 2019-08-27T06:42:48Z | |
| dc.date.available | 2019-08-27T06:42:48Z | |
| dc.date.issued | 2011-02 | |
| dc.description.abstract | Poly(dimethyl siloxane) (PDMS) based films were modified using hydrogels and collagen to produce different types of skin substitute. Poly(hydroxyethyl methacrylate) (PHEMA) and poly(acrylic acid)(PAA) were used via sequential method of interpenetrating polymer networks (IPNs) and blending methods to create suitable functional groups to immobilize collagen in outer layer of PDMS in order to enhance their biocompatibility. Collagen (type I) was covalently linked onto the modified films via coupling agent to activate the hydroxyl groups of PHEMA and the carboxylic groups of PAA. Collagen reacted with the activated groups to obtain covalently linked protein layers. The surface properties of unmodified and modified films were characterised by attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR), X-ray photoelectron spectroscopy (XPS) and scanning electron microscopy (SEM). Dynamic mechanical thermal analysis (DMTA), tensile testing and tear strength measurement were used to investigate the physical and mechanical properties of the modified samples. Water adsorption and water contact angle measurements were performed on the samples in order to evaluate their surface wettability. The aforementioned characterisation techniques indicated that both IPNs and blends samples exhibited more hydrophilicity according to hydrogels content. Grafting of collagen on the surfaces were confirmed using ATR-FTIR and XPS. | en_US |
| dc.identifier.uri | http://hdl.handle.net/123456789/8690 | |
| dc.language.iso | en | en_US |
| dc.publisher | Universiti Sains Malaysia | en_US |
| dc.subject | Collagen Grafted Poly(Dimethyl Siloxane) | en_US |
| dc.subject | Skin Substitute Applications | en_US |
| dc.title | Preparation And Characterization Of Collagen Grafted Poly(Dimethyl Siloxane) Modified Films For Skin Substitute Applications | en_US |
| dc.type | Thesis | en_US |
Files
License bundle
1 - 1 of 1
Loading...
- Name:
- license.txt
- Size:
- 1.71 KB
- Format:
- Item-specific license agreed upon to submission
- Description: