Microbiological And Angiogenic Properties Of Burn Injuries Treated With Tualang Honey Versus Silver-Based Dressing

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dc.contributor.authorMohd Nasir, Nur Azida
dc.date.accessioned2019-06-26T01:55:51Z
dc.date.available2019-06-26T01:55:51Z
dc.date.issued2012-05
dc.description.abstractHoney as a dressing for burn wounds has been widely used. However the potential and the underlying mechanism of action of Tualang honey has not been studied. This project studied the microbiological activities and angiogenic properties of Tualang honey in the treatment of burn injuries. Twenty consented patients with partial thickness burn wound were included in this study. These patients were randomly treated either with hydrofiber®-Tualang honey dressing (n=10) or hydrofiber®-Ag (n=10) dressing. Nine different microorganisms were identified from the swab samples collected. Five were Gram positive namely, Staphylococci, coagulase negative staphylococci, Bacillus subtilis, swarming Proteus spp. and Streptococci. Whereas, Gram negative microorganisms were Enterobacter clocae, Acinetobacter spp., Pseudomonas aeruginosa and Klebsiella pneumoniae. Total bacterial count decreased on day 6 and onwards. In the in-vitro antibacterial study, hydrofiber®-Ag and hydrofiber®-manuka honey dressings gave better zones of inhibition for Gram positive bacteria as compared to hydrofiber®-Tualang honey dressing. However, comparable results were obtained against Gram negative bacteria tested with hydrofiber®-manuka honey and hydrofiber®-Tualang honey dressing. Treated burn tissue samples (n=13) were harvested and tested for the apoptosis using flowcytometry. Only two from the thirteen tissue samples were managed to be cultured and tested for the VEGF and PDGF. The antibacterial properties and apoptosis of partial thickness burn wound treated with hydrofiber®- Tualang honey and hydrofiber®- Ag dressings were comparable. Growth of fibroblast culture from partial thickness burn wound varied in proliferation rate when treated with hydrofiber®- Tualang honey or hydrofiber®- Ag dressings. Fibroblast culture from partial thickness burn treated with hydrofiber®-Ag dressing showed expression of VEGF and PDGF.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/8393
dc.language.isoenen_US
dc.publisherUniversiti Sains Malaysiaen_US
dc.subjectHoney as a dressing for burn woundsen_US
dc.subjecthas been widely useden_US
dc.titleMicrobiological And Angiogenic Properties Of Burn Injuries Treated With Tualang Honey Versus Silver-Based Dressingen_US
dc.typeThesisen_US
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