Serological Evidence Of Dengue Infection In Nonhuman Primates In Peninsular Malaysia
| dc.contributor.author | KEE STUEBING, WILLIAM | |
| dc.date.accessioned | 2016-06-14T07:41:06Z | |
| dc.date.available | 2016-06-14T07:41:06Z | |
| dc.date.issued | 2015-03 | |
| dc.description.abstract | Dengue viruses (DENV) circulate in both human and sylvatic cycles. In 2008, a Malaysian university student was diagnosed with dengue hemorrhagic fever (DHF) and a sylvatic DENV serotype 2 was isolated from his blood. Current information on sylvatic DENV cycles in these heavily populated areas of Malaysia is nonexistent. Sylvatic DENV can cause severe disease (DHF) in humans. Therefore, the objective of this study was to determine the location and host species of sylvatic DENV cycles as a first step in assessing the risk that such zoonotic viruses pose to the surrounding human population. In this study, 430 Macaca fascicularis, six Macaca nemestrina, and six Semnopithecus cristatus monkeys from five states in Peninsular Malaysia were trapped from the wild and screened for DENV-2 neutralizing antibodies using the Plaque Neutralization Reduction Test (PRNT). DENV-2 neutralizing antibodies were found in 67 M. fascicularis (16%) and one M. nemestrina (17%) macaques from Pahang, Negeri Sembilan, and Selangor. Two seropositive monkeys were sampled from areas with a population of 1.8 million people. DENV-2 neutralizing samples were obtained from 20 macaques in a single outing in Negeri Sembilan. The limitations of serological evidence and absence of virus isolation suggest that the DENV-2 neutralizing antibodies detected in this study are evidence for either the presence of sylvatic DENV cycles or of human DENV spillback into macaques living near human populations. Current dengue control measures do not account for the zoonotic spillover of sylvatic strains into the human population or the spillback of human DENV into non-human primates. The blood isolation of a DENV from a macaque is needed to establish the identity of the virus that currently circulates in primates living within these zones of emergence. | en_US |
| dc.identifier.uri | http://hdl.handle.net/123456789/2105 | |
| dc.subject | Serological Evidence Of Dengue Infection In Nonhuman Primates | en_US |
| dc.subject | In Peninsular Malaysia | en_US |
| dc.title | Serological Evidence Of Dengue Infection In Nonhuman Primates In Peninsular Malaysia | en_US |
| dc.type | Thesis | en_US |
Files
License bundle
1 - 1 of 1
Loading...
- Name:
- license.txt
- Size:
- 1.71 KB
- Format:
- Item-specific license agreed upon to submission
- Description: