Histological evidence of adenoid mast cells indicating a role in otitis media with effusion (OME)
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Date
2001-11
Authors
Abdullah, Baharudin
Journal Title
Journal ISSN
Volume Title
Publisher
Universiti Sains Malaysia
Abstract
Otitis media with effusion (OME) is an inflammation of the middle ear in which a
collection of liquid is present in the middle ear space while the tympanic
membrane is intact. The pathogenesis of otitis media is multifactorial which
includes factors such as adenoids hypertrophy, infection (viral or bacteria),
allergy, environment and social factors. The association between adenoid and
OME has long been noted but the exact mechanism is still much debated. We
studied the role of adenoid mast cells in the causation of OME. To study the distribution and a role of adenoid mast cells in the causation of
otitis media with effusion. A cross-sectional prospective study was carried out in Otorhinolaryngologic
Clinic, Department of Otorhinolaryngology (ORL), Science University of
Malaysia (USM) from June 1999 to September 2001. A total number of 50
cases were studied. 25 of the patients studied underwent adenoidectomy while
another 25 patients underwent adenoidectomy and myringotomy with
ventilation tube insertion. The adenoid specimens from all patients were taken and studied for the number of adenoid mast cell using toluidine blue as the
staining agent and light microscopy to count the number of mast cell. The
results were analysed using SPSS version 10. The majority of the patients with chronic adenoiditis had snoring while most of
the patients having otitis media with effusion had hearing impairment.
Audiometry showed most patients having otitis media with effusion had
moderate conductive hearing loss. The population of adenoid mast cell of
children with OME was significantly denser than without OME( p value =
0.000). There is no significant difference between age in the two groups. No
statistically significant correlation was found between race and gender with
outcome. The increased number of adenoid mast cells in patients having otitis media with
effusion suggest that inflammation may play a role in their pathogenesis.
Description
Keywords
Otitis media with effusion (OME)