Evaluation Of The Reproductive And Developmental Toxicities Of The Aqueous Extract Of Labisia Pumila Var. Alata In Female Rats

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dc.contributor.authorMohd Puad, Wan Ezumi
dc.date.accessioned2018-08-06T07:38:02Z
dc.date.available2018-08-06T07:38:02Z
dc.date.issued2009-10
dc.description.abstractLabisia pumila var. alata (LPA) or Kacip Fatimah has been listed by the government of Malaysia as one of the priority species for a multi-disciplinary scientific study towards the development of scientific, evidence-based herbal medicine. The present study described in this thesis is part of the preclinical assessment of LPA to evaluate its safety profile. The aims of this study were to evaluate the potential effects of aqueous extract of LPA on reproductive and developmental toxicities in Sprague Dawley rats. A preliminary study was conducted using unstandardised extract of LPA at 2, 20, 200 and 400 mg/kg/day. Commercially prepared standard aqueous extract of LPA, registered as Biolabisia at the doses of 2, 20, 200, 400, 1000 mg/kg/day or distilled water (control) were administered by gavaging to animals during the main studies. The Teratogenic study was conducted by treating pregnant animals with Biolabisia during the period of organogenesis. Treatments of animals began from the time prior to mating until lactational periods of seven days in the Reproductive toxicity study and from before mating up to day 15 of pregnancy in the Fertility study. Virgin rats were treated with Biolabisia for duration of three weeks in the Female toxicity study. A substantial number of reproductive and developmental parameters were assessed throughout this study. All numerical data were analysed using SPSS version 12.0.1. Results obtained indicated that the administration of Biolabisia at all dose levels did not cause mortality nor show noticeably any treatment-related signs of toxicity on the physical appearance and behaviour of all the rats studied.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/6209
dc.language.isoenen_US
dc.publisherUniversiti Sains Malaysiaen_US
dc.subjectEvaluation Of The Reproductive And Developmental Toxicities Of The Aqueous Extracten_US
dc.subjectLabisia Pumila Var. Alata In Female Ratsen_US
dc.titleEvaluation Of The Reproductive And Developmental Toxicities Of The Aqueous Extract Of Labisia Pumila Var. Alata In Female Ratsen_US
dc.typeThesisen_US
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