Topical latanoprost (PGF2 analogue) for the prevention of immediate increase in intraocular pressure after cataract extraction
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Date
2001-05
Authors
Nik Zaid, Nik Azlan
Journal Title
Journal ISSN
Volume Title
Publisher
Universiti Sains Malaysia
Abstract
The effect of prostaglandin analogue PGF2a. was tested in immediate post-operative
cataract extraction eyes. Seventy-two eyes undergoing endocapsular cataract extraction
with capsular bag intraocular lens implantation using viscoelastic substance were randomly
assigned into two groups. Thirty-six eyes in latanoprost group received 0.005o/o latanoprost
eye drop at the end of the operative procedure while another thirty-six eyes in control group
received a topical drop of placebo ( tetrahydrozoline hydrochloride) similarly. In all other
respects the eyes were treated identically. Intraocular pressure (lOP) was measured preoperatively
and at 3, 6, 9 and 24 hours post-operatively.
Pre-operatively the mean intraocular pressure was 12.31 ± 2.11 mmHg in the latanoprost
group and 12.72 ± 2.49 mmHg in the control group. The mean lOP post-operatively was
persistently higher than the pre-operative levels in both groups. An initial rise in mean lOP
was noted at 6 hours post-operatively (from 17.75 to 21.80 mmHg). Subsequently, the
mean lOP drops with the lowest post-operative lOP was noted at 24 hours post-operatively.
Similar pattern of lOP changes were also seen in latanoprost group, however the mean lOP
levels were always lower than lOP level in control group (from 15.94 to 19.11 mmHg). The
highest mean post-operative lOP was 21.80 ± 7.32 mmHg. recorded in the control group at
6 hours post-operatively. The differences in the mean pressures in the two groups at
corresponding times were not statistically significant (J> > 0.05). In conclusion, a single dose of 0.005% latanoprost given at the end of surgery did not
produce a significant lOP-lowering effect when compared with a control group in the first
24 hour period post-operatively.
Description
Keywords
Cataract extraction eyes