Evaluation Of Statin Association With Hba1c Control, Cognitive Function And Healthcare Professional's Awareness Of Statin Usage Among Diabetic Patients In Penang

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dc.contributor.authorHammad Ali, Mohamed Anwar
dc.date.accessioned2020-07-02T06:31:29Z
dc.date.available2020-07-02T06:31:29Z
dc.date.issued2019-01
dc.description.abstractStatins are the most broadly prescribed class of medications, and their benefits in dyslipidemia therapy and diminishing the hazard for coronary heart disease (CHD) are well reported, but statins effects on non-cardiovascular outcomes are still unclear. This study aimed to assess the epidemiology of statins use and its effect on glycated hemoglobin (HbA1c) control and cognitive impairment among type 2 diabetic patients. Moreover, this study also aimed to measure the prevalence and impact of controlled glycemia (CG) on morbidity and estimated 10-year survival (ES-10Y). Furthermore, it meant to assess the knowledge, attitude, and practice (KAP) of pharmacists and physicians about statins use among the diabetic patients. About 1400 patients were scanned in a cross-sectional study at Hospital Pulau Pinang, Malaysia, the prevalence of statins prescription and CG (HbA1c ≤7%) was assessed. In a prospective cohort study, 213 statin users and 187 statin non-users were followed-up for one year to identify statin effect on glycemic control. Charlson Comorbidity Index (CCI) was used to calculate the confounding impact of comorbidities and to predict ES-10Y among CG and uncontrolled glycemia (UCG). Malay version of Mini-Addenbrooke's Cognitive Examination (M-ACE) was adapted and validated to assess the cognitive impairment among 280 diabetic patients. A KAP survey was constructed and validated to investigate the awareness of 200 healthcare providers about statins usage in diabetic dyslipidemia management (DDM).en_US
dc.identifier.urihttp://hdl.handle.net/123456789/9800
dc.language.isoenen_US
dc.publisherUniversiti Sains Malaysiaen_US
dc.subjectStatin Associationen_US
dc.subjectDiabetic Patientsen_US
dc.titleEvaluation Of Statin Association With Hba1c Control, Cognitive Function And Healthcare Professional's Awareness Of Statin Usage Among Diabetic Patients In Penangen_US
dc.typeThesisen_US
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